Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM08E9O)

Drug Name
Diazepam Drug Info
Synonyms
diazepam; Valium; 439-14-5; Diazemuls; Ansiolisina; Sibazon; Relanium; Faustan; Apaurin; Stesolid; Seduxen; Methyldiazepinone; Valitran; Tranqdyn; Seduksen; Relaminal; Quiatril; Quetinil; Dipezona; Diazetard; Diazepan; Calmpose; Tranimul; Tensopam; Serenack; Paranten; Kiatrium; Domalium; Condition; Bialzepam; Ansiolin; Unisedil; Stesolin; Serenamin; Ruhsitus; Renborin; Quievita; Tranquirit; Serenzin; Neurolytril; Liberetas; Diacepan; Ceregulart; Calmocitene; Bensedin; Atensine; Apozepam; Umbrium; Sonacon; Sedipam; Levium; Diapam; Atilen; Assival; Amiprol; Diazepam (intranasal, epilepsy)
Cross-matching ID
PubChem CID
3016
ChEBI ID
CHEMBL12
CAS Number
CAS 439-14-5
TTD Drug ID
D07JVL
VARIDT Drug ID
DR00999
INTEDE Drug ID
DR0480
ACDINA Drug ID
D00190

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 2.08 0.00e+0 113/158 (71.52%) RPS4Y1;RPS5;RPL13;...
Nitrogen metabolism 2.07 0.00e+0 16/17 (94.12%) CA2;GLUL;CPS1;...
DNA replication 2.01 0.00e+0 34/36 (94.44%) RFC5;LIG1;RFC4;...
Fatty acid degradation -1.62 4.72e-2 40/43 (93.02%) ACSL4;ADH1A;EHHADH;...
Arrhythmogenic right ventricular cardiomyopathy -1.63 4.54e-2 70/77 (90.91%) ITGB6;ITGA10;ITGA2B;...
Systemic lupus erythematosus -1.64 4.31e-2 45/135 (33.33%) CD40;HLA-DPB1;HLA-DQB1;...
Malaria -1.64 4.47e-2 44/50 (88%) VCAM1;SELE;CD40;...
Nicotinate and nicotinamide metabolism -1.65 4.55e-2 25/35 (71.43%) NT5M;NT5C;NMNAT2;...
One carbon pool by folate -1.66 4.58e-2 15/20 (75%) MTR;MTHFD2;TYMS;...
Asthma -1.68 4.23e-2 25/31 (80.65%) CD40;HLA-DPB1;HLA-DQB1;...
Phagosome -1.68 4.55e-2 118/152 (77.63%) CORO1A;ATP6V1G1;HLA-DRB1;...
Type I diabetes mellitus -1.73 3.13e-2 38/43 (88.37%) CD80;HLA-A;PRF1;...
Graft-versus-host disease -1.73 3.20e-2 32/42 (76.19%) CD80;HLA-A;PRF1;...
Riboflavin metabolism -1.84 8.79e-3 7/8 (87.5%) RFK;ACP5;ENPP1
Pantothenate and CoA biosynthesis -1.86 8.88e-3 14/21 (66.67%) PPCS;ALDH3A2;DPYS;...
Steroid biosynthesis -1.88 7.00e-3 19/20 (95%) SQLE;TM7SF2;SOAT1;...
Allograft rejection -1.92 2.28e-3 32/38 (84.21%) CD80;HLA-A;PRF1;...
Autoimmune thyroid disease -1.96 2.67e-3 46/53 (86.79%) TG;CGA;CD80;...
Cell adhesion molecules -1.97 3.20e-3 118/148 (79.73%) CDH2;SDC4;HLA-DRB1;...
Hematopoietic cell lineage -2.00 4.00e-3 90/99 (90.91%) IL1A;CD8B;CD59;...
ECM-receptor interaction -2.01 5.33e-3 80/88 (90.91%) COL6A3;COL9A1;SDC4;...
Intestinal immune network for IgA production -2.02 8.00e-3 38/48 (79.17%) CCR10;HLA-DRB1;CCR9;...
Primary immunodeficiency -2.10 8.00e-3 33/38 (86.84%) ICOS;CD79A;RFX5;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H