Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM08XIN)

• Drug Name: EPIANDROSTERONE Drug Info
• Synonyms: EPIANDROSTERONE; 481-29-8; trans-Androsterone; Isoandrosterone; 3Beta-hydroxy-5alpha-androstan-17-one; 3beta-Hydroxyetioallocholan-17-one; epi-andosterone; 5alpha-Androstan-3beta-ol-17-one; iso-Androsterone; d-Epiandrosterone; UNII-8TR252Z538; 3-Epiandrosterone; (3beta,5alpha)-3-hydroxyandrostan-17-one; CHEMBL272195; 3beta-Hydroxy-androstan-17-one; CHEBI:541975; QGXBDMJGAMFCBF-LUJOEAJASA-N; Androsterone, epi-; NSC 93996; MFCD00064134; 8TR252Z538; ST072176; Androstan-17-one, 3-hydroxy-, (3b,5a)-; epi-Androsterone; C19H30O2
• Cross-matching ID:
  PubChem CID: 441302
  ChEBI ID: CHEMBL272195
  CAS Number: CAS 481-29-8
  TTD Drug ID: D0O8FW

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Malaria	2.27	0.00e+0	44/50 (88%)	IL6;THBS1;CXCL8;...
IL-17 signaling pathway	2.17	0.00e+0	84/94 (89.36%)	IL6;CXCL8;CXCL2;...
TNF signaling pathway	1.91	2.43e-2	103/112 (91.96%)	IL6;CXCL2;ICAM1;...
Rheumatoid arthritis	1.87	4.01e-2	78/93 (83.87%)	IL6;CXCL8;CXCL2;...
Proteasome	1.83	3.79e-2	44/46 (95.65%)	PSMD12;PSMD4;PSME4;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Hide ▲