Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM091H2)

• Drug Name: Pantothenic acid Drug Info
• Synonyms: D-pantothenic acid; pantothenic acid; vitamin B5; 79-83-4; pantothenate; Chick antidermatitis factor; (+)-Pantothenic acid; PANTOTHENOIC ACID; (R)-pantothenate; (D)-(+)-Pantothenic acid; Kyselina pantothenova [Czech]; HSDB 1020; Pantothenic Acid [BAN]; D(+)-N-(2,4-Dihydroxy-3,3-dimethylbutyryl)-beta-alanine; BRN 1727064; UNII-19F5HK2737; (R)-pantothenic acid; beta-Alanine, N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-, (R)-; EINECS 201-229-0; (D,+)-N(alpha-gamma-Dihydroxy-beta,beta-dimethylbutyryl)-beta-alanine
• Cross-matching ID:
  PubChem CID: 6613
  ChEBI ID: CHEMBL46905
  CAS Number: CAS 79-83-4
  TTD Drug ID: D07SJT
  INTEDE Drug ID: DR2054

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Glycolysis / Gluconeogenesis	1.93	0.00e+0	56/67 (83.58%)	PFKL;ALDOB;ADH1B;...
Pentose phosphate pathway	1.87	3.03e-2	25/30 (83.33%)	PFKL;ALDOB;GPI;...
Complement and coagulation cascades	1.86	2.02e-2	76/85 (89.41%)	F3;CD55;SERPINA1;...
Platelet activation	1.83	2.12e-2	106/124 (85.48%)	PLCB1;ROCK2;TBXA2R;...
Dopaminergic synapse	1.83	1.69e-2	115/132 (87.12%)	PLCB1;GNG11;PPP2R2B;...
African trypanosomiasis	1.82	1.41e-2	32/37 (86.49%)	PLCB1;IDO1;LAMA4;...
Fructose and mannose metabolism	1.77	2.42e-2	30/33 (90.91%)	PFKL;ALDOB;GMDS;...
Carbohydrate digestion and absorption	1.75	3.33e-2	37/47 (78.72%)	PLCB1;SLC37A4;MGAM;...
Gap junction	1.74	3.63e-2	72/88 (81.82%)	PLCB1;PDGFRA;GUCY1A1;...
Adrenergic signaling in cardiomyocytes	1.72	4.12e-2	130/150 (86.67%)	PLCB1;ATP2A3;PPP2R2B;...
Asthma	-2.03	0.00e+0	25/31 (80.65%)	IL9;HLA-DMB;RNASE3;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	15uM	72H	Hide ▲