Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM09Z35)

• Drug Name: bilobalide Drug Info
• Synonyms: Bilobalide; 33570-04-6; Bilobalid; (-)-Bilobalide; UNII-M81D2O8H7U; CHEBI:3103; M81D2O8H7U; Bilobalide A; 4H,5aH,9H-Furo(2,3-b)furo(3',2':2,3)cyclopenta(1,2-c)furan-2,4,7(3H,8H)-trione, 9-(1,1-dimethylethyl)-10,10a-dihydro-8,9-dihydroxy-, (5aR-(3aS*,5aalpha,8beta,8aS*,9alpha,10aalpha))-; (3aS,8R,8aS,9R,10aS)-9-tert-butyl-8,9-dihydroxydihydro-9H-furo[2,3-b]furo[3',2':2,3]cyclopenta[1,2-c]furan-2,4,7(3H,8H)-trione; tert-butyl(dihydroxy)[ ]trione; C15H18O8; Bilobalide;; Bilobalide A;; ( )-Bilobalide; AC1L2K4G; MLS000563448
• Cross-matching ID:
  PubChem CID: 73581
  ChEBI ID: CHEMBL3103
  CAS Number: CAS 33570-04-6
  TTD Drug ID: D0B0TK

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Cholesterol metabolism	-1.72	4.14e-2	44/50 (88%)	LCAT;LPA;VDAC2;...
Cysteine and methionine metabolism	-1.75	4.04e-2	43/50 (86%)	GOT2;MAT2B;SRM;...
Pyruvate metabolism	-1.77	3.74e-2	41/47 (87.23%)	FH;ADH7;ALDH2;...
Protein export	-1.81	2.73e-2	17/23 (73.91%)	SRP14;SRP72;SEC61A1;...
Ferroptosis	-1.86	1.71e-2	36/41 (87.8%)	LPCAT3;VDAC2;ATG7;...
Pertussis	-1.90	9.75e-3	64/76 (84.21%)	C1R;TNF;MAPK13;...
Retinol metabolism	-2.22	0.00e+0	41/68 (60.29%)	CYP26B1;UGT2B15;RETSAT;...
Complement and coagulation cascades	-2.92	0.00e+0	76/85 (89.41%)	C1R;VWF;FGA;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲