Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM0D7LA)

Drug Name
BROMODEOXYURIDINE Drug Info
Synonyms
5-BROMO-2'-DEOXYURIDINE; 59-14-3; Broxuridine; Bromodeoxyuridine; 5-Bromodeoxyuridine; BRDU; 5-BrdU; BUDR; 5-Bromouracil deoxyriboside; Bromouracil deoxyriboside; 5-Bromodesoxyuridine; 5-Bdu; Broxuridinum; Broxuridina; 5-Bromouracil-2-deoxyriboside; 5-Bromo-2-deoxyuridine; bromodeoxyuridine (brdu); Broxuridinum [INN-Latin]; Uridine, 5-bromo-2'-deoxy-; Broxuridina [INN-Spanish]; C9H11BrN2O5; NSC-38297; Bromoouridine; Radibud; CCRIS 818; Brudr; UNII-G34N38R2N1; HSDB 7477; CHEBI:472552; EINECS 200-415-9; 5-Budr; 5-bromo-2'-deoxy uridine
Cross-matching ID
PubChem CID
6035
ChEBI ID
CHEMBL222280
CAS Number
CAS 59-14-3
TTD Drug ID
D0M4MA

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cardiac muscle contraction 1.92 2.33e-2 64/87 (73.56%) TPM4;COX7A1;ASPH;...
Apelin signaling pathway 1.89 2.33e-2 117/137 (85.4%) MYLK;SPP1;ACTA2;...
Regulation of actin cytoskeleton 1.87 2.33e-2 185/218 (84.86%) CXCL12;MYLK;SRC;...
Complement and coagulation cascades 1.81 3.49e-2 76/85 (89.41%) CLU;F13A1;C3;...
beta-Alanine metabolism 1.80 2.80e-2 25/30 (83.33%) ALDH3A1;ALDH2;GAD2;...
Hematopoietic cell lineage 1.77 3.69e-2 90/99 (90.91%) ANPEP;CD36;CD1E;...
Ascorbate and aldarate metabolism 1.77 3.83e-2 15/30 (50%) ALDH2;UGDH;ALDH3A2;...
Proximal tubule bicarbonate reclamation 1.75 3.79e-2 21/23 (91.3%) AQP1;CA2;ATP1A2;...
Staphylococcus aureus infection 1.74 4.01e-2 72/95 (75.79%) KRT19;C3;KRT23;...
Ribosome biogenesis in eukaryotes -2.25 0.00e+0 52/108 (48.15%) RPP38;RAN;RCL1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H