Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM0DQM5)

• Drug Name: Amlexanox Drug Info
• Synonyms: ANW; Amlenanox; Amlexanoxo; Amlexanoxum; Amoxanox; Aphthasol; Aptheal; Apthera; Elics; OraDisc; OraRinse; Solfa; Amlexanoxo [Spanish]; Amlexanoxum [Latin]; GlaxoSmithKline brand of amlexanox; OraDisc A; AA 673; CHX 3673; AA-673; Aphthasol (TN); CHX-3673; Solfa (TN); Amlexanox [USAN:INN:JAN]; Amlexanox (JAN/USAN/INN); 2-Amino-7-isopropyl-5-oxo-5H-(1)benzopyrano(2,3-b)pyridine-3-carboxylic acid; 2-amino-5-oxo-7-(propan-2-yl)-5H-chromeno[2,3-b]pyridine-3-carboxylic acid; 2-amino-5-oxo-7-propan-2-ylchromeno[2,3-b]pyridine-3-carboxylic acid; 2-amino-7-(1-methylethyl)-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid; 2-amino-7-isopropyl-5-oxo-5H-(1)benzopyrano(2,3b)pyridine-3-carboxylic acid
• Therapeutic Class: Antiulcer Agents
• Cross-matching ID:
  PubChem CID: 2161
  ChEBI ID: CHEMBL1096
  CAS Number: CAS 68302-57-8
  TTD Drug ID: D0G5UB
  ACDINA Drug ID: D00836

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Mineral absorption	2.17	0.00e+0	48/60 (80%)	MT1E;MT1X;MT1F;...
DNA replication	2.03	0.00e+0	34/36 (94.44%)	MCM5;POLE2;MCM2;...
Antigen processing and presentation	1.97	3.64e-3	60/78 (76.92%)	HLA-DRA;CD74;HLA-DRB1;...
Viral protein interaction with cytokine and cytokine re...	1.95	5.46e-3	84/100 (84%)	CXCL14;CXCL13;CXCL12;...
Allograft rejection	1.92	8.74e-3	32/38 (84.21%)	HLA-DRA;HLA-DRB1;HLA-B;...
Porphyrin and chlorophyll metabolism	1.90	1.09e-2	23/43 (53.49%)	PPOX;HMOX1;ALAS2;...
Type I diabetes mellitus	1.83	1.87e-2	38/43 (88.37%)	HLA-DRA;HLA-DRB1;HLA-B;...
Graft-versus-host disease	1.79	2.87e-2	32/42 (76.19%)	HLA-DRA;HLA-DRB1;HLA-B;...
Systemic lupus erythematosus	1.78	2.79e-2	45/135 (33.33%)	HLA-DRA;HLA-DRB1;C1S;...
Viral myocarditis	1.75	3.71e-2	53/60 (88.33%)	HLA-DRA;HLA-DRB1;HLA-B;...
Glycine, serine and threonine metabolism	1.75	3.38e-2	31/40 (77.5%)	MAOB;GATM;ALAS2;...
One carbon pool by folate	1.73	4.10e-2	15/20 (75%)	TYMS;SHMT1;AMT;...
Glycolysis / Gluconeogenesis	1.73	3.95e-2	56/67 (83.58%)	GPI;ENO2;PCK1;...
Proximal tubule bicarbonate reclamation	1.70	4.53e-2	21/23 (91.3%)	CA2;AQP1;PCK1;...
Renin-angiotensin system	1.68	4.92e-2	20/23 (86.96%)	CPA3;ANPEP;ENPEP;...
Dilated cardiomyopathy	-1.96	2.92e-3	86/96 (89.58%)	SGCA;CACNA1S;ITGA2B;...
Cardiac muscle contraction	-2.02	0.00e+0	64/87 (73.56%)	CACNA1S;CACNA2D1;SLC8A1;...
Hypertrophic cardiomyopathy	-2.13	0.00e+0	81/90 (90%)	SGCA;CACNA1S;ITGA2B;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.04uM - 10uM	24H	Show ▼