Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM0E9BR)

Drug Name
Staurosporine Drug Info
Synonyms
staurosporine; Staurosporin; (+)-Staurosporine; Antibiotic 230; 62996-74-1; Antibiotic AM 2282; CCRIS 3272; AM-2282; UNII-H88EPA0A3N; Alkaloid AM-2282 from Streptomyces; H88EPA0A3N; CHEMBL388978; CHEBI:15738; CGP 39360; 8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)trinden-1-one, 2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-10-(methylamino)-, (8alpha,9beta,10beta,12alpha)-(+)-
Cross-matching ID
PubChem CID
44259
ChEBI ID
CHEMBL388978
CAS Number
CAS 62996-74-1
TTD Drug ID
D0E3TC
VARIDT Drug ID
DR00790

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Valine, leucine and isoleucine degradation 2.12 0.00e+0 42/48 (87.5%) ALDH7A1;ACAA1;HADH;...
One carbon pool by folate 2.05 5.52e-3 15/20 (75%) AMT;SHMT2;DHFR;...
Glycine, serine and threonine metabolism 1.89 2.21e-2 31/40 (77.5%) AMT;SHMT2;PSAT1;...
Complement and coagulation cascades 1.89 1.66e-2 76/85 (89.41%) C3;CFB;A2M;...
Platelet activation 1.85 1.99e-2 106/124 (85.48%) F2R;GUCY1A1;PRKCI;...
Fatty acid degradation 1.84 1.84e-2 40/43 (93.02%) ECI1;ALDH7A1;ACAA1;...
Cysteine and methionine metabolism 1.81 1.89e-2 43/50 (86%) AHCY;PSAT1;CBS;...
Glyoxylate and dicarboxylate metabolism 1.81 1.79e-2 23/30 (76.67%) AMT;SHMT2;ACO2;...
Taurine and hypotaurine metabolism 1.78 2.08e-2 8/11 (72.73%) CSAD;CDO1;GGT1;...
Ribosome 1.76 2.21e-2 113/158 (71.52%) RPL36;RPS5;RPS4Y1;...
Retrograde endocannabinoid signaling 1.76 2.21e-2 118/148 (79.73%) NDUFS7;NDUFA7;MGLL;...
Alanine, aspartate and glutamate metabolism 1.75 2.30e-2 27/37 (72.97%) ALDH5A1;GLUD1;ASNS;...
Tyrosine metabolism 1.74 2.29e-2 30/36 (83.33%) AOX1;ADH1C;MAOA;...
Oxidative phosphorylation 1.68 3.94e-2 93/133 (69.92%) PPA1;ATP5F1D;NDUFS7;...
Diabetic cardiomyopathy 1.67 4.34e-2 162/203 (79.8%) ATP5F1D;NDUFS7;AKT3;...
Linoleic acid metabolism 1.66 4.62e-2 21/29 (72.41%) CYP2J2;CYP1A2;PLA2G6;...
Pyruvate metabolism 1.66 4.35e-2 41/47 (87.23%) ALDH7A1;ACYP2;GLO1;...
Cell cycle -1.74 3.86e-2 110/124 (88.71%) CDKN2D;ORC4;CDC23;...
MicroRNAs in cancer -1.76 3.77e-2 146/310 (47.1%) SIRT1;RAF1;MMP16;...
Progesterone-mediated oocyte maturation -1.78 3.40e-2 75/100 (75%) CDC23;RPS6KA3;CDC25C;...
Legionellosis -1.81 3.20e-2 51/57 (89.47%) IL6;ARF1;CASP9;...
Ribosome biogenesis in eukaryotes -1.82 3.11e-2 52/108 (48.15%) REXO2;EFL1;POP7;...
Glycosaminoglycan biosynthesis -1.87 2.29e-2 40/58 (68.97%) CHST7;B3GAT3;CHPF2;...
Proteasome -1.88 2.74e-2 44/46 (95.65%) PSMA1;PSMD6;PSMB7;...
Protein processing in endoplasmic reticulum -2.00 4.57e-3 127/171 (74.27%) SEL1L;BAX;HSP90AB1;...
Spliceosome -2.10 0.00e+0 101/150 (67.33%) FUS;SF3B5;NCBP1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.37uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 1.11uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H