Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM0EP7M)

• Drug Name: Minaprine Drug Info
• Synonyms: Brantur; Cantor; Minaprina; Minaprinum; Minaprine dihydrochloride; AGR 1240; CB 30038; Cantor (TN); Minaprina [INN-Spanish]; Minaprinum [INN-Latin]; Minaprine (USAN/INN); Minaprine [USAN:BAN:INN]; N-(4-Methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine; 3-(morpholinoethyl)amino-4-methyl-6-phenylpyridazine; 4-(2-((4-Methyl-6-phenyl-3-pyridazinyl)amino)ethyl)morpholine; 4-Methyl-3-(2-morpholinoethylamino)-6-phenylpyridazin; 4-methyl-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine
• Therapeutic Class: Antidepressants
• Cross-matching ID:
  PubChem CID: 4199
  ChEBI ID: CHEMBL51038
  CAS Number: CAS 25905-77-5
  TTD Drug ID: D0W8SJ
  INTEDE Drug ID: DR1093

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Systemic lupus erythematosus	2.43	0.00e+0	45/135 (33.33%)	C1S;C1QA;C1R;...
DNA replication	2.21	0.00e+0	34/36 (94.44%)	RFC2;MCM6;PRIM1;...
Citrate cycle (TCA cycle)	1.81	3.67e-2	30/30 (100%)	IDH2;ACO2;SUCLG1;...
Mismatch repair	1.81	3.12e-2	22/23 (95.65%)	RFC2;RFC3;RPA2;...
Base excision repair	1.78	3.38e-2	29/33 (87.88%)	POLE2;APEX1;FEN1;...
Type I diabetes mellitus	1.75	3.91e-2	38/43 (88.37%)	HLA-DMB;HLA-DQB1;FAS;...
Allograft rejection	1.74	3.77e-2	32/38 (84.21%)	CD40;HLA-DMB;HLA-DQB1;...
Ovarian steroidogenesis	-1.77	3.91e-2	41/51 (80.39%)	PRKACB;SCARB1;PRKACA;...
Breast cancer	-1.83	2.60e-2	119/147 (80.95%)	RPS6KB1;FGF9;DLL3;...
Renal cell carcinoma	-1.84	3.04e-2	68/69 (98.55%)	ARNT;PIK3CD;SOS2;...
Hepatocellular carcinoma	-1.84	3.38e-2	135/168 (80.36%)	PLCG2;PIK3R1;GSTM1;...
Mineral absorption	-1.94	1.30e-2	48/60 (80%)	MT1M;ATP1A1;ATP1B3;...
Basal cell carcinoma	-1.94	1.74e-2	41/63 (65.08%)	GSK3B;LEF1;DDB2;...
Steroid hormone biosynthesis	-1.94	2.60e-2	43/61 (70.49%)	UGT2B15;CYP1A1;HSD17B7;...
Gastric cancer	-2.14	1.30e-2	122/149 (81.88%)	RARB;RPS6KB1;FGF9;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.04uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.01uM - 2.22uM	24H	Show ▼