Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM0FB1J)

Drug Name
Sertraline Drug Info
Synonyms
Lustral; SRE; Sertralina; Sertralinum; Sertralina [Spanish]; Sertraline [Zoloft]; Sertralinum [Latin]; CP 51974; Cp 51974; Apo-Sertraline; Lustral (TN); Sertraline (INN); Sertraline (Zoloft); Sertraline [INN:BAN]; Zoloft (TN); (+)-Sertraline; (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine; (1S-cis)-1,2,3,4-Tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-1-naphthalenamine; (1S-cis)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine
Therapeutic ClassAntidepressants
Cross-matching ID
PubChem CID
68617
ChEBI ID
CHEMBL809
CAS Number
CAS 79617-96-2
TTD Drug ID
D0K0TC
VARIDT Drug ID
DR00440
INTEDE Drug ID
DR1477
ACDINA Drug ID
D00620

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
PPAR signaling pathway 2.29 0.00e+0 66/74 (89.19%) SCD;HMGCS1;FADS2;...
Lysosome 2.29 0.00e+0 115/128 (89.84%) NPC1;TPP1;NEU1;...
Terpenoid backbone biosynthesis 2.23 0.00e+0 18/22 (81.82%) HMGCS1;IDI1;FDPS;...
Steroid biosynthesis 2.21 0.00e+0 19/20 (95%) MSMO1;SQLE;DHCR7;...
Biosynthesis of unsaturated fatty acids 2.18 0.00e+0 21/27 (77.78%) SCD;FADS1;FADS2;...
Steroid hormone biosynthesis 1.88 2.37e-2 43/61 (70.49%) CYP1B1;HSD17B7;SRD5A1;...
Butanoate metabolism 1.81 3.42e-2 23/28 (82.14%) HMGCS1;ACAT2;AACS
Synthesis and degradation of ketone bodies 1.80 3.22e-2 9/10 (90%) HMGCS1;ACAT2
Synaptic vesicle cycle 1.80 3.35e-2 63/78 (80.77%) ATP6V1C1;ATP6V1B2;STX3;...
Ferroptosis 1.79 3.02e-2 36/41 (87.8%) HMOX1;GPX4;ACSL3;...
Metabolism of xenobiotics by cytochrome P450 1.77 3.47e-2 49/77 (63.64%) CYP1B1;AKR7A3;GSTA1;...
AMPK signaling pathway 1.76 3.84e-2 106/120 (88.33%) SCD;HMGCR;FASN;...
Glycosaminoglycan degradation 1.76 3.75e-2 19/19 (100%) HEXB;NAGLU;GLB1;...
Fatty acid biosynthesis 1.76 3.48e-2 16/18 (88.89%) FASN;ACSL3;ACACA;...
Other glycan degradation 1.76 3.25e-2 13/18 (72.22%) NEU1;HEXB;MANBA;...
Vibrio cholerae infection 1.76 3.16e-2 44/50 (88%) ATP6V1C1;SLC12A2;ATP6V1B2;...
mTOR signaling pathway 1.72 3.97e-2 114/154 (74.03%) LPIN1;RRAGC;RRAGD;...
Pentose phosphate pathway 1.71 3.99e-2 25/30 (83.33%) PGD;ALDOC;TKT;...
Cholesterol metabolism 1.70 4.34e-2 44/50 (88%) NPC1;LDLR;NPC2;...
Renin-angiotensin system 1.70 4.12e-2 20/23 (86.96%) CTSA;CPA3;MME;...
Chagas disease -1.68 4.11e-2 93/102 (91.18%) MYD88;FASLG;TGFBR2;...
Cardiac muscle contraction -1.70 3.42e-2 64/87 (73.56%) MYL3;HRC;MYH6;...
Cocaine addiction -1.71 3.52e-2 42/49 (85.71%) CDK5R1;CREB5;GRIA2;...
Spliceosome -1.78 1.83e-2 101/150 (67.33%) SNRPD3;LSM5;DHX8;...
RNA transport -1.80 1.47e-2 128/186 (68.82%) RAN;EIF4G2;EIF3J;...
Mismatch repair -1.81 1.68e-2 22/23 (95.65%) RPA4;MLH1;MSH6;...
RNA polymerase -1.81 1.96e-2 23/31 (74.19%) POLR3G;POLR2H;POLR2K;...
Ribosome -1.86 7.04e-3 113/158 (71.52%) RPS26;RPL3L;RPS27A;...
IL-17 signaling pathway -1.91 2.94e-3 84/94 (89.36%) FOSL1;IFNG;IL6;...
Proximal tubule bicarbonate reclamation -1.98 3.91e-3 21/23 (91.3%) ATP1B1;CA4;ATP1A2;...
DNA replication -2.10 0.00e+0 34/36 (94.44%) RNASEH2A;MCM7;RNASEH2B;...
Legionellosis -2.10 0.00e+0 51/57 (89.47%) CLK4;IL6;HBS1L;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H