Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM0G5O6)

Drug Name
Flumatinib Drug Info
Synonyms HH-GV-678
Cross-matching ID
PubChem CID
46848036
ChEBI ID
CHEMBL3545413
CAS Number
CAS 895519-90-1
TTD Drug ID
D06JHV

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.32 0.00e+0 19/20 (95%) MSMO1;SQLE;DHCR7;...
Terpenoid backbone biosynthesis 2.15 0.00e+0 18/22 (81.82%) HMGCS1;IDI1;ACAT2;...
Glyoxylate and dicarboxylate metabolism 2.09 3.60e-3 23/30 (76.67%) ACAT2;GLUL;DLD;...
Synthesis and degradation of ketone bodies 2.06 2.70e-3 9/10 (90%) HMGCS1;ACAT2;HMGCS2
Lysosome 2.06 2.16e-3 115/128 (89.84%) NPC2;GM2A;TPP1;...
Citrate cycle (TCA cycle) 2.04 1.80e-3 30/30 (100%) IDH1;ACLY;DLD;...
Amino sugar and nucleotide sugar metabolism 1.95 3.08e-3 38/48 (79.17%) GNPDA1;HK2;AMDHD2;...
Pentose phosphate pathway 1.91 4.05e-3 25/30 (83.33%) TKT;PGD;ALDOC;...
Butanoate metabolism 1.91 3.60e-3 23/28 (82.14%) HMGCS1;ACAT2;HMGCS2;...
Tryptophan metabolism 1.87 4.32e-3 35/42 (83.33%) ACAT2;DHTKD1;KMO;...
Asthma 1.87 3.93e-3 25/31 (80.65%) CD40;HLA-DQB1;HLA-DMB;...
Biosynthesis of unsaturated fatty acids 1.86 4.50e-3 21/27 (77.78%) SCD;FADS1;ELOVL6;...
PPAR signaling pathway 1.85 4.98e-3 66/74 (89.19%) HMGCS1;SCD;DBI;...
Valine, leucine and isoleucine degradation 1.85 4.63e-3 42/48 (87.5%) HMGCS1;ACAT2;HMGCS2;...
Starch and sucrose metabolism 1.82 5.04e-3 25/36 (69.44%) MGAM;PYGB;HK2;...
Arginine and proline metabolism 1.80 6.75e-3 39/50 (78%) GATM;CKB;ALDH2;...
Nitrogen metabolism 1.79 8.89e-3 16/17 (94.12%) CA2;GLUL;GLUD1;...
Regulation of lipolysis in adipocytes 1.78 9.00e-3 52/55 (94.55%) IRS2;ADCY1;PTGER3;...
Cholesterol metabolism 1.75 1.31e-2 44/50 (88%) LDLR;NPC2;LIPA;...
Central carbon metabolism in cancer 1.75 1.40e-2 67/70 (95.71%) IDH1;SIRT3;PKM;...
Ovarian steroidogenesis 1.72 2.31e-2 41/51 (80.39%) LDLR;HSD17B7;ADCY1;...
Arginine biosynthesis 1.72 2.21e-2 17/22 (77.27%) GLUL;GLUD1;ARG2;...
Cortisol synthesis and secretion 1.70 2.30e-2 58/65 (89.23%) LDLR;ADCY1;ADCY2;...
Fructose and mannose metabolism 1.70 2.56e-2 30/33 (90.91%) ALDOC;HK2;PFKP;...
Bile secretion 1.64 4.32e-2 68/90 (75.56%) CA2;ABCC4;HMGCR;...
Renin-angiotensin system 1.63 4.65e-2 20/23 (86.96%) CPA3;AGT;CTSA;...
Mineral absorption -1.82 3.40e-2 48/60 (80%) HMOX1;ATP2B1;HEPH;...
Pertussis -1.82 4.53e-2 64/76 (84.21%) CALML3;TLR4;IL23A;...
IL-17 signaling pathway -2.18 0.00e+0 84/94 (89.36%) CSF3;LCN2;MMP1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H