Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM0HPWY)

Drug Name
biochanin A Drug Info
Synonyms
Biochanin A; 491-80-5; Biochanin; 4'-Methylgenistein; 5,7-Dihydroxy-4'-methoxyisoflavone; 5,7-Dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one; Genistein 4-methyl ether; 5,7-Dihydrox -4'-methoxyisoflavone; Biochanine A; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-methoxyphenyl)-; olmelin; Pratensol; NSC 123538; Biochanin-A; 5,7-dihydroxy-3-(4-methoxyphenyl)chromen-4-one; 4-Methylgenistein; C16H12O5; UNII-U13J6U390T; CCRIS 5449; 5,7-Dihydroxy-3-p-methoxyphenyl-4H-chromen-4-one; EINECS 207-744-7; NSC123538; Genistein 4'-methyl ether; 4'-methylgenistein; BIOCHANIN
Cross-matching ID
PubChem CID
5280373
ChEBI ID
CHEMBL131921
CAS Number
CAS 491-80-5
TTD Drug ID
D0S9YX

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 1.82 4.17e-2 34/36 (94.44%) RPA3;RFC5;RNASEH2A;...
Ovarian steroidogenesis -1.73 4.95e-2 41/51 (80.39%) STAR;SCARB1;PRKACA;...
Bladder cancer -1.75 3.77e-2 40/41 (97.56%) KRAS;MAP2K1;MAPK3;...
Aldosterone-regulated sodium reabsorption -1.77 3.60e-2 34/37 (91.89%) PIK3R2;PDPK1;INS;...
VEGF signaling pathway -1.80 3.60e-2 50/59 (84.75%) AKT1;PIK3CB;PPP3R1;...
Mitophagy -1.97 8.99e-3 56/68 (82.35%) CALCOCO2;KRAS;USP8;...
Endocrine and other factor-regulated calcium reabsorpti... -1.98 7.99e-3 49/53 (92.45%) ATP1B2;RAB11A;DNM2;...
Proximal tubule bicarbonate reclamation -2.00 1.20e-2 21/23 (91.3%) PCK1;ATP1B3;CA4;...
Steroid biosynthesis -2.16 0.00e+0 19/20 (95%) DHCR7;CYP51A1;SOAT1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H