Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM0HR5W)

Drug Name
BMS-181100 Drug Info
Synonyms BMY-14786; BMY-14802; BMY-14802 hydrochloride; MJ-14676; MJ-14786; MJ-14802; BMY-14802, Skybridge; BMY-14802-1; BMY-14802 (dyskinesia), Skybridge; 5-HT 1a receptor agonist (dyskinesia), Skybridge
Cross-matching ID
PubChem CID
108046
ChEBI ID
CHEMBL60859
CAS Number
CAS 105565-56-8
TTD Drug ID
D01YOC

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 2.16 0.00e+0 113/158 (71.52%) RPS4Y1;RSL24D1;MRPS7;...
Pyrimidine metabolism 1.96 2.85e-3 40/56 (71.43%) DCK;NME1;CTPS1;...
Ribosome biogenesis in eukaryotes 1.89 5.70e-3 52/108 (48.15%) NVL;NOP56;POP5;...
Proteasome 1.84 1.14e-2 44/46 (95.65%) PSMC6;PSMD11;PSMD4;...
Aminoacyl-tRNA biosynthesis 1.76 2.51e-2 15/66 (22.73%) QRSL1;NARS2;GATC;...
Basal transcription factors 1.72 3.71e-2 37/45 (82.22%) GTF2A2;CDK7;TAF9;...
Glycosaminoglycan degradation -1.67 4.61e-2 19/19 (100%) IDUA;HPSE;HYAL1;...
Cocaine addiction -1.68 4.70e-2 42/49 (85.71%) ATF4;RELA;MAOB;...
Biosynthesis of unsaturated fatty acids -1.71 3.49e-2 21/27 (77.78%) FADS1;ACOT7;ACAA1;...
Other glycan degradation -1.71 3.70e-2 13/18 (72.22%) MAN2B2;MAN2C1;HEXA;...
Tryptophan metabolism -1.72 3.14e-2 35/42 (83.33%) ALDH3A2;MAOB;HADHA;...
Small cell lung cancer -1.73 3.07e-2 90/92 (97.83%) LAMC2;BIRC7;LAMB4;...
ECM-receptor interaction -1.77 2.39e-2 80/88 (90.91%) ITGA4;THBS3;HSPG2;...
Selenocompound metabolism -1.80 1.93e-2 11/17 (64.71%) PAPSS1;PAPSS2
Fatty acid degradation -1.84 9.31e-3 40/43 (93.02%) ALDH3A2;ACSL1;ADH6;...
Arginine and proline metabolism -1.86 6.35e-3 39/50 (78%) CKB;ALDH4A1;OAT;...
Lysosome -1.87 5.58e-3 115/128 (89.84%) CTSO;AP3M2;ATP6V0B;...
Retinol metabolism -1.88 6.20e-3 41/68 (60.29%) CYP3A4;DGAT1;ALDH1A3;...
Parathyroid hormone synthesis, secretion and action -1.89 5.24e-3 98/106 (92.45%) MAPK3;ITPR2;LRP5;...
Glycolysis / Gluconeogenesis -1.90 5.98e-3 56/67 (83.58%) PCK1;PCK2;ALDH9A1;...
Valine, leucine and isoleucine degradation -1.90 6.98e-3 42/48 (87.5%) OXCT2;ALDH3A2;PCCB;...
Tyrosine metabolism -1.92 5.58e-3 30/36 (83.33%) HPD;MAOB;ADH6;...
Fructose and mannose metabolism -1.95 0.00e+0 30/33 (90.91%) TKFC;ENOSF1;KHK;...
Transcriptional misregulation in cancer -1.97 0.00e+0 158/192 (82.29%) SPINT1;NSD2;DUSP6;...
Pentose phosphate pathway -1.99 0.00e+0 25/30 (83.33%) H6PD;PGM1;RBKS;...
Mineral absorption -2.02 0.00e+0 48/60 (80%) ATOX1;MT1M;MT1F;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 3.33uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H