Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM0HS92)

Drug Name
Merimepodib Drug Info
Synonyms
Merimebodib; Merimepodib [USAN:INN]; Tyverb/Tykerb; MMPD; 198821-22-6; 2ZL2BA06FU; C23H24N4O6; CHEMBL304087; MERIMEPODIB, VI-21497, VX-497; UNII-2ZL2BA06FU; VI-21497; VX-497; VX497; Vx 497; carbamic acid
Cross-matching ID
PubChem CID
153241
ChEBI ID
CHEMBL304087
CAS Number
CAS 198821-22-6
TTD Drug ID
D0F0ZE

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Metabolism of xenobiotics by cytochrome P450 2.40 0.00e+0 49/77 (63.64%) GSTO1;AKR1C1;CYP2E1;...
Drug metabolism 2.14 0.00e+0 78/151 (51.66%) GSTO1;CES1;CYP2E1;...
Histidine metabolism 1.99 0.00e+0 16/22 (72.73%) ALDH3A1;ALDH3B1;HNMT;...
Phenylalanine metabolism 1.96 0.00e+0 14/17 (82.35%) ALDH3A1;ALDH3B1;MAOB;...
Retinol metabolism 1.95 2.01e-3 41/68 (60.29%) ALDH1A3;ALDH1A1;UGT2B28;...
Graft-versus-host disease 1.95 3.35e-3 32/42 (76.19%) IL1A;HLA-DMB;HLA-DRA;...
Oxidative phosphorylation 1.92 4.30e-3 93/133 (69.92%) COX6B1;NDUFA1;COX5B;...
Glutathione metabolism 1.89 5.02e-3 43/57 (75.44%) GPX1;GSTO1;GSTP1;...
Steroid hormone biosynthesis 1.86 4.46e-3 43/61 (70.49%) AKR1C3;AKR1C2;AKR1C1;...
beta-Alanine metabolism 1.86 4.02e-3 25/30 (83.33%) ALDH3A1;ALDH3B1;ALDH6A1;...
Tyrosine metabolism 1.83 9.13e-3 30/36 (83.33%) ALDH3A1;ALDH3B1;ADH1B;...
Pentose phosphate pathway 1.83 9.20e-3 25/30 (83.33%) RBKS;ALDOB;PRPS2;...
Peroxisome 1.82 9.27e-3 72/82 (87.8%) PHYH;IDH2;MPV17;...
TGF-beta signaling pathway 1.81 1.22e-2 81/94 (86.17%) ID1;ID4;ID3;...
Folate biosynthesis 1.80 1.61e-2 23/26 (88.46%) AKR1C3;QDPR;AKR1B10;...
Allograft rejection 1.75 2.64e-2 32/38 (84.21%) HLA-DMB;HLA-DRA;GZMB;...
p53 signaling pathway 1.73 2.54e-2 63/73 (86.3%) CDKN1A;CHEK2;TP53I3;...
Type I diabetes mellitus 1.69 3.68e-2 38/43 (88.37%) IL1A;HLA-DMB;HLA-DRA;...
Arachidonic acid metabolism 1.68 3.75e-2 48/61 (78.69%) AKR1C3;GPX1;CYP2E1;...
Huntington disease 1.67 4.02e-2 233/306 (76.14%) POLR2I;GPX1;PLCB1;...
Tryptophan metabolism 1.67 3.97e-2 35/42 (83.33%) KYNU;CYP1B1;CYP1A1;...
Spliceosome -1.82 4.97e-2 101/150 (67.33%) PUF60;HSPA6;TRA2B;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H