Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM0J92L)

Drug Name
Benactyzine Drug Info
Synonyms
BENACTYZINE; Benactyzin; Benzactyzine; 302-40-9; Diethylaminoethyl benzilate; Benactizina; Benactizina [DCIT]; Benactizina [Italian]; 2-(Diethylamino)ethyl benzilate; Benactyzine [INN:BAN]; Benactyzinum [INN-Latin]; Benacticina [INN-Spanish]; 2-Diethylaminoethyl benzilate; UNII-595EG71R3F; 2-(Diethylamino)ethyl diphenylglycolate; HSDB 3292; Benzilic acid, 2-(diethylamino)ethyl ester; EINECS 206-123-8; Diphenylglycolic acid 2-(diethylamino)ethyl ester; BRN 2156821; Benzilic acid beta-diethylaminoethyl ester; CHEMBL70352
Cross-matching ID
PubChem CID
9330
ChEBI ID
CHEMBL94775
CAS Number
CAS 302-40-9
TTD Drug ID
D07KYU

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Drug metabolism 2.29 0.00e+0 78/151 (51.66%) ADH1B;ALDH3A1;GSTA4;...
Retinol metabolism 2.07 5.27e-3 41/68 (60.29%) ADH1B;ALDH1A1;AOX1;...
Systemic lupus erythematosus 2.02 3.52e-3 45/135 (33.33%) C1S;C1R;SNRPB;...
Ascorbate and aldarate metabolism 1.98 2.64e-3 15/30 (50%) ALDH2;ALDH3A2;RGN;...
Allograft rejection 1.95 6.33e-3 32/38 (84.21%) CD40;HLA-DRB1;HLA-DPA1;...
Autoimmune thyroid disease 1.90 8.79e-3 46/53 (86.79%) CD40;HLA-DRB1;HLA-DPA1;...
Pentose and glucuronate interconversions 1.87 1.36e-2 17/34 (50%) AKR1B10;UGT2A3;UGT2B4;...
Fatty acid degradation 1.84 1.58e-2 40/43 (93.02%) ADH1B;ALDH2;ACADVL;...
Complement and coagulation cascades 1.76 2.70e-2 76/85 (89.41%) C1S;C1R;TFPI;...
Pyruvate metabolism 1.75 2.85e-2 41/47 (87.23%) ADH1B;ALDH2;ALDH3A2;...
Metabolism of xenobiotics by cytochrome P450 1.72 3.45e-2 49/77 (63.64%) ADH1B;ALDH3A1;GSTA4;...
Intestinal immune network for IgA production 1.70 3.69e-2 38/48 (79.17%) CD40;HLA-DRB1;HLA-DPA1;...
PPAR signaling pathway 1.70 3.41e-2 66/74 (89.19%) CD36;FABP5;ACAA1;...
Staphylococcus aureus infection 1.68 3.62e-2 72/95 (75.79%) C1S;C1R;KRT14;...
African trypanosomiasis 1.68 3.94e-2 32/37 (86.49%) PLCB1;IDO1;LAMA4;...
Steroid biosynthesis -2.06 0.00e+0 19/20 (95%) MSMO1;NSDHL;HSD17B7;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H