Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM0JE6N)

• Drug Name: Metixene Drug Info
• Synonyms: Atosil; Contalyl; Dalpan; METHIXENE; Methixart; Methixen; Methyloxan; Metisene; Metixeno; Metixenum; Raunana; Tremaril;Tremarit; Tremonil; Tremoquil; Trest; Methixen [German]; Methixene hydrochloride; Metisene [DCIT]; Metixene hydrochloride; Tremaril hydrochloride; Metixene (INN); Metixene (TN); Metixene [INN:BAN]; Metixeno [INN-Spanish]; Metixenum [INN-Latin]; Methixene (*hydrochloride*); Metixene (*hydrochloride*); Tremonil (*hydrochloride*); 1-Methyl-3-(9H-thioxanthen-9-yl-methyl)piperidine; 1-Methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine; 1-Methyl-3-(thioxanthen-9-ylmethyl) piperidine; 1-Methyl-3-(thioxanthen-9-ylmethyl)-1-piperidine; 1-methyl-3-(thioxanthen-9-ylmethyl)-piperidine hydrochloride; 60 SJ 1977; 60 SJ 1977 (*hydrochloride*); 9-(1'-Methylpiperidine-3'-methyl)thioxanthene
• Therapeutic Class: Antiparkinson Agents
• Cross-matching ID:
  PubChem CID: 4167
  ChEBI ID: CHEMBL51024
  CAS Number: CAS 4969-02-2
  TTD Drug ID: D0NF0W

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Biosynthesis of unsaturated fatty acids	2.05	0.00e+0	21/27 (77.78%)	SCD;FADS1;HACD1;...
Steroid biosynthesis	1.85	4.48e-2	19/20 (95%)	DHCR24;DHCR7;CYP51A1;...
Glycolysis / Gluconeogenesis	-1.59	4.66e-2	56/67 (83.58%)	ALDH3A1;DLAT;ALDH2;...
Protein export	-1.59	4.86e-2	17/23 (73.91%)	SPCS1;SRP9;SRP14;...
Neuroactive ligand-receptor interaction	-1.61	4.71e-2	294/341 (86.22%)	HTR1F;MLNR;P2RY4;...
Rheumatoid arthritis	-1.62	4.93e-2	78/93 (83.87%)	TNF;IL23A;ATP6V0A4;...
Glycine, serine and threonine metabolism	-1.62	4.92e-2	31/40 (77.5%)	BHMT;DLD;CTH;...
Type I diabetes mellitus	-1.65	3.97e-2	38/43 (88.37%)	PTPRN;TNF;CD80;...
Mineral absorption	-1.66	3.69e-2	48/60 (80%)	TF;FTL;STEAP1;...
Tyrosine metabolism	-1.70	3.02e-2	30/36 (83.33%)	AOX1;ADH6;TYR;...
Pathways of neurodegeneration	-1.70	2.89e-2	354/475 (74.53%)	RAB5A;DCTN1;ATG14;...
Pyruvate metabolism	-1.75	1.61e-2	41/47 (87.23%)	LDHA;ACYP2;PDHB;...
Cysteine and methionine metabolism	-1.76	1.58e-2	43/50 (86%)	LDHA;LDHB;MDH1;...
Ribosome	-1.76	1.70e-2	113/158 (71.52%)	RPL10A;MRPS18C;RPS28;...
Graft-versus-host disease	-1.78	1.59e-2	32/42 (76.19%)	TNF;KIR2DL1;CD80;...
Thermogenesis	-1.78	1.64e-2	173/232 (74.57%)	MAPK13;NDUFB5;COX10;...
Amyotrophic lateral sclerosis	-1.81	1.41e-2	267/364 (73.35%)	NEFM;NDUFS4;COX6A2;...
Folate biosynthesis	-1.85	1.12e-2	23/26 (88.46%)	DHFR;PTS;GPHN;...
Huntington disease	-1.88	8.79e-3	233/306 (76.14%)	GPX2;COX7B;VDAC2;...
Malaria	-1.94	5.74e-3	44/50 (88%)	TLR4;TGFB2;CCL2;...
Retinol metabolism	-1.96	6.70e-3	41/68 (60.29%)	AOX1;CYP2C8;ADH6;...
Proteasome	-1.99	4.02e-3	44/46 (95.65%)	PSMD1;PSMA6;PSMD6;...
Proximal tubule bicarbonate reclamation	-2.02	2.51e-3	21/23 (91.3%)	FXYD2;MDH1;GLS;...
Prion disease	-2.03	3.35e-3	209/273 (76.56%)	MAPK13;NDUFB5;PSMD1;...
Parkinson disease	-2.29	0.00e+0	176/249 (70.68%)	GNAL;NDUFB5;PARK7;...
Oxidative phosphorylation	-2.57	0.00e+0	93/133 (69.92%)	NDUFB5;COX10;ATP6V0A4;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	6.66uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼