Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM0KJDY)

Drug Name
LY2801653 Drug Info
Synonyms
Merestinib; LY2801653; 1206799-15-6; LY-2801653; UNII-5OGS5K699E; N-(3-fluoro-4-((1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl)oxy)phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide; 5OGS5K699E; N-(3-Fluoro-4-{[1-Methyl-6-(1h-Pyrazol-4-Yl)-1h-Indazol-5-Yl]oxy}phenyl)-1-(4-Fluorophenyl)-6-Methyl-2-Oxo-1,2-Dihydropyridine-3-Carboxamide; C30H22F2N6O3; Merestinib [USAN]; SCHEMBL679002; LY2801653 (Merestinib); GTPL9841; CHEMBL3545307; QCR-139; DTXSID20659635; SYN1222; QHADVLVFMKEIIP-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
44603533
ChEBI ID
CHEMBL3545307
CAS Number
CAS 1206799-15-6
TTD Drug ID
D06EGV

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Wnt signaling pathway 1.93 0.00e+0 124/166 (74.7%) SFRP1;MMP7;DKK1;...
Protein digestion and absorption 1.82 4.49e-2 78/103 (75.73%) CPA3;COL4A5;COL4A6;...
Hippo signaling pathway 1.81 3.76e-2 120/186 (64.52%) TGFBR2;BMP4;PAK1;...
Phagosome -1.62 4.89e-2 118/152 (77.63%) HLA-A;HLA-DPB1;C1R;...
Dopaminergic synapse -1.64 4.56e-2 115/132 (87.12%) KCNJ6;ITPR3;PPP2R1A;...
Steroid hormone biosynthesis -1.64 4.69e-2 43/61 (70.49%) CYP17A1;AKR1C2;CYP3A7;...
Glycosaminoglycan degradation -1.64 4.68e-2 19/19 (100%) HYAL4;SGSH;GUSB;...
Mineral absorption -1.66 3.73e-2 48/60 (80%) SLC34A2;ATP1A3;SLC26A3;...
Other glycan degradation -1.67 3.35e-2 13/18 (72.22%) HEXA;HEXB;MAN2B1;...
Prion disease -1.68 3.28e-2 209/273 (76.56%) MAPK9;NDUFS8;C8G;...
Pentose and glucuronate interconversions -1.68 3.43e-2 17/34 (50%) DCXR;AKR1B1;UGT2B17;...
Glutamatergic synapse -1.70 2.92e-2 97/114 (85.09%) PPP3CB;GNG10;SLC1A2;...
Complement and coagulation cascades -1.71 2.75e-2 76/85 (89.41%) C8G;FGA;A2M;...
Protein export -1.78 1.45e-2 17/23 (73.91%) SEC11A;SEC61B;SPCS3;...
Graft-versus-host disease -1.78 1.54e-2 32/42 (76.19%) HLA-A;HLA-DPB1;IL6;...
Linoleic acid metabolism -1.78 1.63e-2 21/29 (72.41%) PLA2G2D;CYP3A4;PLA2G1B;...
Alcoholism -1.79 1.66e-2 86/186 (46.24%) HDAC6;CAMK4;GNG10;...
Vibrio cholerae infection -1.80 1.60e-2 44/50 (88%) ATP6V0B;ADCY9;ACTB;...
Type I diabetes mellitus -1.82 1.34e-2 38/43 (88.37%) HSPD1;ICA1;GAD2;...
Lysosome -1.83 1.24e-2 115/128 (89.84%) CLTC;HYAL2;GGA3;...
Retrograde endocannabinoid signaling -1.84 1.13e-2 118/148 (79.73%) MAPK9;NDUFS8;NDUFB5;...
Huntington disease -1.87 7.46e-3 233/306 (76.14%) PSMC4;GRIA4;NDUFA2;...
Oxidative phosphorylation -1.88 6.91e-3 93/133 (69.92%) NDUFA2;NDUFS3;ATP5F1E;...
Antigen processing and presentation -1.90 4.66e-3 60/78 (76.92%) HSPA6;RFXANK;B2M;...
Pertussis -1.92 5.33e-3 64/76 (84.21%) IL10;JUN;MAPK9;...
Autoimmune thyroid disease -1.97 2.07e-3 46/53 (86.79%) HLA-A;HLA-DPB1;CD40;...
Parkinson disease -1.98 2.49e-3 176/249 (70.68%) NDUFC1;ATF6;PSMD9;...
Allograft rejection -1.99 3.11e-3 32/38 (84.21%) HLA-A;HLA-DPB1;CD40;...
Metabolism of xenobiotics by cytochrome P450 -2.09 0.00e+0 49/77 (63.64%) ADH1C;AKR1C1;EPHX1;...
Synaptic vesicle cycle -2.13 0.00e+0 63/78 (80.77%) CLTCL1;UNC13B;ATP6V1A;...
Proteasome -2.20 0.00e+0 44/46 (95.65%) PSMA6;PSMB1;PSMB7;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H