Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM0L594)

Drug Name
Ivabradine Drug Info
Synonyms
Ivabradine; 155974-00-8; Procoralan; Corlanor; Corlentor; UNII-3H48L0LPZQ; S 16257; S-16257; S-16257-2; S 16257-2; 3H48L0LPZQ; CHEMBL471737; CHEBI:85966; C27H36N2O5; 7,8-Dimethoxy-3-(3-(((4,5-dimethoxybenzocyclobutan-1-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-2H-benzazepin-2-one; S-16260-2; s16257; (S)-3-(3-(((3,4-Dimethoxybicyclo(4.2.0)octa-1,3,5-trien-7-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one; Ivabradine [INN]
Cross-matching ID
PubChem CID
132999
ChEBI ID
CHEMBL471737
CAS Number
CAS 155974-00-8
TTD Drug ID
D0S9QA
INTEDE Drug ID
DR0897
ACDINA Drug ID
D00338

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Spliceosome 2.55 0.00e+0 101/150 (67.33%) LSM5;HSPA1A;HNRNPM;...
mRNA surveillance pathway 1.80 3.67e-2 71/98 (72.45%) PNN;GSPT2;PCF11;...
Nicotine addiction -1.68 4.76e-2 32/40 (80%) GABRB2;GABRA3;GRIN2A;...
Ovarian steroidogenesis -1.68 4.87e-2 41/51 (80.39%) CYP19A1;CYP17A1;PLA2G4A;...
Peroxisome -1.69 4.45e-2 72/82 (87.8%) ABCD1;GSTK1;SLC25A17;...
GABAergic synapse -1.70 4.57e-2 76/89 (85.39%) KCNJ6;GABRB1;GABARAPL2;...
Phagosome -1.70 4.89e-2 118/152 (77.63%) PIK3C3;TLR4;ATP6V0C;...
Riboflavin metabolism -1.71 4.21e-2 7/8 (87.5%) RFK;ENPP1;ACP5;...
Cocaine addiction -1.71 4.34e-2 42/49 (85.71%) CDK5;MAOA;ATF4;...
Vibrio cholerae infection -1.72 4.48e-2 44/50 (88%) TJP1;ATP6V0C;ACTB;...
Fluid shear stress and atherosclerosis -1.73 4.11e-2 123/139 (88.49%) MAP2K5;MGST2;DUSP1;...
Synaptic vesicle cycle -1.76 3.04e-2 63/78 (80.77%) ATP6V1H;TCIRG1;ATP6V0E2;...
Graft-versus-host disease -1.77 3.25e-2 32/42 (76.19%) HLA-C;HLA-G;FAS;...
NOD-like receptor signaling pathway -1.80 2.15e-2 145/181 (80.11%) ITPR1;MFN1;GBP1;...
Collecting duct acid secretion -1.82 2.28e-2 22/27 (81.48%) TCIRG1;ATP6V0E2;ATP6V1F;...
IL-17 signaling pathway -1.85 1.92e-2 84/94 (89.36%) S100A7;IL17RC;CXCL10;...
TNF signaling pathway -1.93 1.03e-2 103/112 (91.96%) CX3CL1;MAP3K8;CXCL10;...
Epithelial cell signaling in Helicobacter pylori infect... -1.93 1.37e-2 62/70 (88.57%) JAM2;TJP1;ATP6V0C;...
Rheumatoid arthritis -1.95 1.37e-2 78/93 (83.87%) ICAM1;ATP6V1H;ACP5;...
Mitophagy -1.95 2.74e-2 56/68 (82.35%) MFN1;PINK1;AMBRA1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H