Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM0LKHV)

Drug Name
B7-2/GM-CSF Drug Info
Cross-matching ID
PubChem CID
9862248
ChEBI ID
CHEMBL107400
CAS Number
CAS 211110-63-3
TTD Drug ID
D01QXY

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.23 0.00e+0 34/36 (94.44%) RFC5;MCM2;MCM5;...
Ribosome biogenesis in eukaryotes 1.84 3.73e-2 52/108 (48.15%) HEATR1;NVL;RPP40;...
Oxytocin signaling pathway -1.71 4.80e-2 128/154 (83.12%) ITPR3;PLA2G4A;RYR2;...
JAK-STAT signaling pathway -1.73 4.69e-2 146/162 (90.12%) IL12A;STAT5A;SOS1;...
ErbB signaling pathway -1.74 4.10e-2 79/85 (92.94%) CRKL;ERBB2;PAK4;...
Long-term potentiation -1.77 3.35e-2 61/67 (91.04%) GRIN2D;RAPGEF3;CAMK2A;...
Bladder cancer -1.78 2.34e-2 40/41 (97.56%) MMP1;ERBB2;ARAF;...
Melanoma -1.85 1.88e-2 68/72 (94.44%) FGF22;PDGFA;ARAF;...
Apelin signaling pathway -1.85 1.46e-2 117/137 (85.4%) SMAD2;NOS1;ADCY8;...
Glutamatergic synapse -1.93 7.81e-3 97/114 (85.09%) PLCB2;TRPC1;GRM4;...
GnRH secretion -2.00 0.00e+0 60/64 (93.75%) PRKCG;GPER1;PLCB2;...
GABAergic synapse -2.05 0.00e+0 76/89 (85.39%) PRKCG;ADCY8;CACNA1B;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H