Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM0N3L7)

• Drug Name: Ethopropazine Drug Info
• Synonyms: Aethopropropazin; Athapropazine; Athopropazin; Ethapropazine; Ethopromazine; Etopropezina; Fempropazine; Fenpropazina; Isopthazine; Isotazin; Isothazine; Isothiazine; Lysivane; Parcidol; Pardidol; Parfezine; Parkin; Parkisol; Parsidan; Parsidol; Parsitan; Parsotil; Phenopropazine; Phenoprozine; Prodictazin; Prodierazine; Profenamina; Profenamine; Profenaminum; Prophenamine; Prophenaminum; Rochipel; Rocipel; Rodipal; Profenamina [Italian]; RP 3356; SC 2538; SKF 2538; W 483; Parkin (TN); Parsidan (TN); Parsidol(TN); Profenamina [INN-Spanish]; Profenamine (INN); Profenamine [INN:BAN]; Profenaminum [INN-Latin]; N,N-Diethyl-alpha-methyl-10H-phenothiazine-10-ethanamine; N,N-diethyl-1-phenothiazin-10-ylpropan-2-amine; N,N-Diethyl-1-(10H-phenothiazin-10-yl)-2-propanamine; N,N-diethyl-1-(10H-phenothiazin-10-yl)propan-2-amine; 10-(2-Diethylaminopropyl)phenothiazine; 10-[2-(Diethylamino)-1-Propyl]phenothiazine;10-[2-(Diethylamino)-2-methylethyl]phenothiazine; 10-[2-(Diethylamino)propyl]phenothiazine; 2-Diethylamino-1-propyl-N-dibenzoparathiazine
• Therapeutic Class: Antiparkinson Agents
• Cross-matching ID:
  PubChem CID: 3290
  ChEBI ID: CHEMBL1206
  CAS Number: CAS 522-00-9
  TTD Drug ID: D0Q0RC
  VARIDT Drug ID: DR00996
  INTEDE Drug ID: DR2283

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	2.53	0.00e+0	19/20 (95%)	SQLE;MSMO1;DHCR24;...
Biosynthesis of unsaturated fatty acids	1.97	4.87e-3	21/27 (77.78%)	SCD;FADS1;HACD1;...
Oxidative phosphorylation	1.90	6.50e-3	93/133 (69.92%)	ATP6V1D;ATP5F1E;COX7C;...
Glutathione metabolism	1.89	7.31e-3	43/57 (75.44%)	GSTA1;PGD;MGST3;...
Terpenoid backbone biosynthesis	1.84	1.56e-2	18/22 (81.82%)	HMGCS1;ACAT2;IDI1;...
Steroid hormone biosynthesis	1.78	2.76e-2	43/61 (70.49%)	CYP1B1;AKR1C2;AKR1C1;...
Vibrio cholerae infection	1.76	3.48e-2	44/50 (88%)	GNAS;ATP6V1D;ATP6AP1;...
Amoebiasis	-1.65	4.65e-2	99/102 (97.06%)	CD1A;NFKB1;GNA11;...
Primary immunodeficiency	-1.68	3.95e-2	33/38 (86.84%)	BTK;CD19;CD3D;...
Apoptosis	-1.70	3.47e-2	126/168 (75%)	FAS;GADD45B;ITPR3;...
Natural killer cell mediated cytotoxicity	-1.71	3.25e-2	99/131 (75.57%)	LCK;NRAS;PPP3CC;...
NOD-like receptor signaling pathway	-1.73	2.61e-2	145/181 (80.11%)	MEFV;CYBA;PLCB1;...
Legionellosis	-1.77	1.84e-2	51/57 (89.47%)	NFKB1;CYCS;EEF1A2;...
Mineral absorption	-1.83	9.11e-3	48/60 (80%)	MT1HL1;ATP2B3;MT1G;...
Pertussis	-1.85	8.97e-3	64/76 (84.21%)	C1QA;CXCL5;MAPK9;...
Pyrimidine metabolism	-1.91	4.39e-3	40/56 (71.43%)	NT5M;DCK;RRM1;...
NF-kappa B signaling pathway	-1.91	5.12e-3	90/104 (86.54%)	LCK;NFKBIA;EDA2R;...
Systemic lupus erythematosus	-1.92	6.15e-3	45/135 (33.33%)	C8B;CD40;C6;...
TNF signaling pathway	-2.02	5.12e-3	103/112 (91.96%)	JUNB;IL6;IL15;...
Viral protein interaction with cytokine and cytokine re...	-2.03	3.42e-3	84/100 (84%)	CXCL6;TNFRSF14;CXCR1;...
Ribosome biogenesis in eukaryotes	-2.03	5.12e-3	52/108 (48.15%)	RCL1;NXF2;POP5;...
IL-17 signaling pathway	-2.29	0.00e+0	84/94 (89.36%)	IL6;MMP13;NFKBIA;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H, 24H	Hide ▲

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H, 24H	Show ▼