Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM0N8ZM)

Drug Name
COUMARIN Drug Info
Synonyms
coumarin; 2H-Chromen-2-one; 91-64-5; 2H-1-Benzopyran-2-one; cumarin; 1,2-Benzopyrone; Rattex; Tonka bean camphor; Coumarinic anhydride; chromen-2-one; Coumarine; Benzo-alpha-pyrone; cis-o-Coumarinic acid lactone; o-Hydroxycinnamic acid lactone; o-Hydroxycinnamic lactone; 2-Oxo-1,2-benzopyran; Coumarinic lactone; Kumarin; Benzo-a-pyrone; Kumarin [Czech]; 5,6-Benzo-2-pyrone; 2H-1-Benzopyran, 2-oxo-; 5,6-Benzo-alpha-pyrone; 2H-Benzo(b)pyran-2-one; 2H-Benzo[b]pyran-2-one; Caswell No. 259C; o-Coumaric acid lactone
Cross-matching ID
PubChem CID
323
ChEBI ID
CHEMBL6466
CAS Number
CAS 91-64-5
TTD Drug ID
D03ZMQ
VARIDT Drug ID
DR00864
INTEDE Drug ID
DR0386

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Pyrimidine metabolism 2.17 0.00e+0 40/56 (71.43%) ENPP1;CTPS1;RRM1;...
DNA replication 1.91 4.89e-3 34/36 (94.44%) MCM5;MCM2;POLA2;...
Base excision repair 1.88 1.30e-2 29/33 (87.88%) FEN1;PARP1;POLD1;...
Mismatch repair 1.84 1.22e-2 22/23 (95.65%) MLH3;EXO1;POLD1;...
Ether lipid metabolism -1.71 3.96e-2 32/49 (65.31%) PLPP1;PAFAH1B1;PLA2G4A;...
Sulfur metabolism -1.72 3.85e-2 9/10 (90%) PAPSS1;ETHE1;PAPSS2
Mineral absorption -1.72 4.05e-2 48/60 (80%) MT1F;ATP2B1;MT1G;...
Glycosaminoglycan degradation -1.74 3.80e-2 19/19 (100%) HYAL3;HEXB;HEXA;...
Systemic lupus erythematosus -1.76 4.20e-2 45/135 (33.33%) ELANE;HLA-DMB;CD40;...
Amino sugar and nucleotide sugar metabolism -1.77 4.39e-2 38/48 (79.17%) MPI;GPI;FPGT;...
Lysosome -1.97 1.01e-2 115/128 (89.84%) HEXB;LGMN;GGA1;...
Staphylococcus aureus infection -2.00 1.01e-2 72/95 (75.79%) DEFA5;DEFA6;KRT16;...
Complement and coagulation cascades -2.16 0.00e+0 76/85 (89.41%) TFPI;CFD;C3AR1;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 1.25uM - 40uM 3H, 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H