General Information of Drug (ID: DM0PMKW)

Drug Name
OG-L002 Drug Info
Synonyms
OG-L002; 1357302-64-7; 4'-((1R,2S)-2-aminocyclopropyl)-[1,1'-biphenyl]-3-ol; SCHEMBL6837351; GTPL7023; OGL002; AOB2070; MolPort-035-395-885; BDBM179446; BCP12278; EX-A2117; s7237; 2610AH; ZINC114026926; AKOS027422749; SB19352; BC600435; 4'-((1R,2S)-2-aminocyclopropyl)biphenyl-3-ol; 3-{4-[(1R,2S)-2-aminocyclopropyl]phenyl}phenol; J-006764; US9676701, 4 4'-((trans)-2-aminocyclopropyl)biphenyl-3-ol hydrochloride
Cross-matching ID
PubChem CID
56639570
ChEBI ID
CHEMBL4289507
TTD Drug ID
D0C8SX

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Asthma 1.91 5.86e-2 25/31 (80.65%) HLA-DQB1;PRG2;FCER1A;...
Alcoholism 1.74 1.90e-1 86/186 (46.24%) GNG11;PKIA;GNAI1;...
DNA replication 1.64 3.35e-1 34/36 (94.44%) PCNA;FEN1;POLE2;...
Proteasome 1.60 4.13e-1 44/46 (95.65%) PSMA6;PSMB5;PSMC3;...
Oxidative phosphorylation 1.55 5.00e-1 93/133 (69.92%) NDUFB3;NDUFAB1;NDUFB6;...
Steroid biosynthesis 1.53 4.67e-1 19/20 (95%) SC5D;DHCR24;HSD17B7;...
Systemic lupus erythematosus 1.52 4.62e-1 45/135 (33.33%) HLA-DQB1;C7;CTSG;...
Renin secretion 1.51 4.30e-1 61/69 (88.41%) GNAI1;GUCY1A1;KCNJ2;...
Melanogenesis 1.50 4.33e-1 74/101 (73.27%) GNAI1;CREB1;FZD2;...
Parkinson disease 1.49 3.95e-1 176/249 (70.68%) GNAI1;GPR37;SLC6A3;...
Vasopressin-regulated water reabsorption 1.49 3.75e-1 40/44 (90.91%) AQP3;CREB1;GNAS;...
Hematopoietic cell lineage 1.48 3.63e-1 90/99 (90.91%) CD36;HLA-DQB1;CD55;...
Regulation of lipolysis in adipocytes 1.47 3.69e-1 52/55 (94.55%) GNAI1;PTGS2;NPY;...
Phagosome 1.47 3.47e-1 118/152 (77.63%) CD36;HLA-DQB1;TLR4;...
Valine, leucine and isoleucine degradation 1.46 3.27e-1 42/48 (87.5%) HMGCS2;HMGCS1;AOX1;...
Viral myocarditis 1.45 3.33e-1 53/60 (88.33%) HLA-DQB1;CD55;HLA-DMB;...
Synaptic vesicle cycle 1.45 3.13e-1 63/78 (80.77%) SLC1A1;SLC6A3;ATP6V1A;...
Base excision repair 1.45 3.01e-1 29/33 (87.88%) PCNA;FEN1;POLE2;...
Renin-angiotensin system 1.44 3.03e-1 20/23 (86.96%) CTSG;ENPEP;CPA3;...
Serotonergic synapse 1.43 3.27e-1 97/114 (85.09%) GNG11;GNAI1;PTGS2;...
Ras signaling pathway 1.41 3.54e-1 201/232 (86.64%) GNG11;EGF;RAPGEF5;...
Nucleotide excision repair 1.39 4.09e-1 40/47 (85.11%) PCNA;RAD23B;POLE2;...
Diabetic cardiomyopathy 1.38 4.10e-1 162/203 (79.8%) CD36;PLN;ATP2A1;...
Intestinal immune network for IgA production 1.38 3.98e-1 38/48 (79.17%) HLA-DQB1;CXCL12;HLA-DMB;...
Circadian entrainment 1.34 4.88e-1 85/97 (87.63%) GNG11;RPS6KA5;GNAI1;...
Arachidonic acid metabolism 1.34 4.71e-1 48/61 (78.69%) PTGS2;ALOX5;PLAAT3;...
Synthesis and degradation of ketone bodies 1.33 4.82e-1 9/10 (90%) HMGCS2;HMGCS1;BDH2;...
Calcium signaling pathway 1.33 4.65e-1 213/240 (88.75%) EGF;PDGFD;NTRK2;...
Drug metabolism 1.31 5.20e-1 78/151 (51.66%) FMO1;UGT2B28;GSTA1;...
Alzheimer disease 1.30 5.18e-1 279/369 (75.61%) DKK1;PTGS2;ATP2A1;...
Porphyrin and chlorophyll metabolism -1.27 4.34e-1 23/43 (53.49%) FECH;ALAS2;HEPH
Coronavirus disease -1.29 4.26e-1 215/232 (92.67%) VWF;C9;EGFR;...
Measles -1.29 4.35e-1 133/139 (95.68%) FADD;RELA;BBC3;...
Mannose type O-glycan biosynthesis -1.31 3.97e-1 14/23 (60.87%) B3GAT1;B4GALT3;LARGE1;...
Fructose and mannose metabolism -1.33 3.71e-1 30/33 (90.91%) PFKFB3;SORD;HKDC1;...
Galactose metabolism -1.33 3.85e-1 26/31 (83.87%) B4GALT2;GALT;HKDC1;...
GnRH secretion -1.36 3.36e-1 60/64 (93.75%) CACNA1C;ARRB2;ARRB1;...
Inositol phosphate metabolism -1.36 3.41e-1 66/73 (90.41%) ITPKA;PIK3CG;TPI1;...
Focal adhesion -1.38 3.24e-1 180/201 (89.55%) COL6A1;COL4A5;PTEN;...
Amino sugar and nucleotide sugar metabolism -1.39 3.11e-1 38/48 (79.17%) GALT;HKDC1;CHIA;...
TNF signaling pathway -1.39 3.19e-1 103/112 (91.96%) JUNB;MAPK13;IL6;...
Sulfur metabolism -1.39 3.28e-1 9/10 (90%) MPST;SELENBP1;TST
Rheumatoid arthritis -1.40 3.37e-1 78/93 (83.87%) CTSK;IL1A;ATP6AP1;...
RIG-I-like receptor signaling pathway -1.41 3.13e-1 64/70 (91.43%) MAPK14;IFNA1;IRF3;...
Glycolysis / Gluconeogenesis -1.42 3.10e-1 56/67 (83.58%) TPI1;G6PC3;PDHA2;...
Thyroid hormone synthesis -1.43 3.01e-1 66/75 (88%) GPX1;TPO;GPX7;...
Neomycin, kanamycin and gentamicin biosynthesis -1.45 2.80e-1 5/5 (100%) HKDC1;HK2;HK1
NOD-like receptor signaling pathway -1.47 2.61e-1 145/181 (80.11%) HSP90AA1;MAPK13;IL6;...
Vitamin digestion and absorption -1.47 2.78e-1 17/24 (70.83%) SLC19A2;SCARB1;APOA1;...
Legionellosis -1.48 2.93e-1 51/57 (89.47%) C3;CXCL1;BNIP3;...
Central carbon metabolism in cancer -1.53 2.05e-1 67/70 (95.71%) PDHA2;LDHAL6B;AKT1;...
Amoebiasis -1.54 2.12e-1 99/102 (97.06%) COL4A6;LAMC1;SERPINB4;...
Other types of O-glycan biosynthesis -1.58 1.65e-1 29/47 (61.7%) GALNT8;B4GALT2;COLGALT1;...
ECM-receptor interaction -1.59 1.74e-1 80/88 (90.91%) COL6A1;COL4A5;COL9A3;...
Small cell lung cancer -1.59 2.03e-1 90/92 (97.83%) RELA;CDKN1B;COL4A5;...
Epithelial cell signaling in Helicobacter pylori infect... -1.62 2.02e-1 62/70 (88.57%) MAPK13;JUN;HBEGF;...
Cholesterol metabolism -1.65 1.60e-1 44/50 (88%) APOC1;ANGPTL8;VDAC1;...
IL-17 signaling pathway -1.77 5.85e-2 84/94 (89.36%) TRAF5;TRAF4;LCN2;...
Mineral absorption -1.81 6.71e-2 48/60 (80%) MT2A;MT1G;MT1H;...
Bladder cancer -1.89 6.20e-2 40/41 (97.56%) FGFR3;E2F3;ERBB2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H