Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM0QDC9)

Drug Name
Dolastatin 10 Drug Info
Synonyms
Dolastatin 10; Dolastatin-10; Dolostatin 10; UNII-EI946JT51X; CCRIS 7310; CHEBI:67357; NSC 376128; EI946JT51X; L-Valinamide, N,N-dimethyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-
Cross-matching ID
PubChem CID
9810929
ChEBI ID
CHEMBL39541
CAS Number
CAS 110417-88-4
VARIDT Drug ID
DR01505

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Focal adhesion 2.42 0.00e+0 180/201 (89.55%) CAV1;ACTN1;ITGA6;...
Amoebiasis 2.16 0.00e+0 99/102 (97.06%) ACTN1;CXCL3;CXCL1;...
Salmonella infection 2.09 0.00e+0 198/249 (79.52%) PODXL;FLNA;TUBB2A;...
Regulation of actin cytoskeleton 2.01 0.00e+0 185/218 (84.86%) ACTN1;ITGA6;ITGA5;...
Bacterial invasion of epithelial cells 1.99 0.00e+0 59/77 (76.62%) CAV1;CAV2;ILK;...
Leukocyte transendothelial migration 1.99 0.00e+0 90/114 (78.95%) ACTN1;ACTN4;PRKCA;...
Yersinia infection 1.94 1.71e-3 120/137 (87.59%) ITGA5;IL1B;RPS6KA2;...
ECM-receptor interaction 1.94 1.49e-3 80/88 (90.91%) ITGA6;ITGA5;THBS1;...
Pathogenic Escherichia coli infection 1.90 1.33e-3 152/197 (77.16%) TUBB2A;IL1B;MYO5A;...
Mineral absorption 1.89 1.19e-3 48/60 (80%) MT1E;MT1H;MT1HL1;...
Proteoglycans in cancer 1.88 1.09e-3 172/205 (83.9%) CAV1;CAV2;ITGA5;...
Renal cell carcinoma 1.86 4.97e-3 68/69 (98.55%) HRAS;CRK;ETS1;...
Hypertrophic cardiomyopathy 1.86 4.59e-3 81/90 (90%) TPM1;ITGA6;TPM4;...
Dilated cardiomyopathy 1.85 4.26e-3 86/96 (89.58%) TPM1;ITGA6;TPM4;...
IL-17 signaling pathway 1.83 3.98e-3 84/94 (89.36%) CXCL3;FOSL1;CXCL1;...
Shigellosis 1.82 3.73e-3 180/246 (73.17%) ACTN1;ILK;ITGA5;...
AGE-RAGE signaling pathway in diabetic complications 1.76 1.62e-2 97/100 (97%) F3;PRKCA;IL1B;...
Tight junction 1.74 1.79e-2 130/169 (76.92%) ACTN1;ACTN4;MYH9;...
Arrhythmogenic right ventricular cardiomyopathy 1.74 1.70e-2 70/77 (90.91%) ITGA6;ITGA5;ITGA3;...
Small cell lung cancer 1.73 1.61e-2 90/92 (97.83%) ITGA6;LAMC2;COL4A2;...
Proteasome 1.73 1.54e-2 44/46 (95.65%) PSMA7;PSMD9;PSMD2;...
NF-kappa B signaling pathway 1.73 1.52e-2 90/104 (86.54%) CXCL3;CXCL1;IL1B;...
Long-term potentiation 1.72 1.51e-2 61/67 (91.04%) PRKCA;RPS6KA2;HRAS;...
VEGF signaling pathway 1.70 1.84e-2 50/59 (84.75%) PRKCA;HRAS;SPHK1;...
Colorectal cancer 1.70 1.81e-2 84/86 (97.67%) AREG;BIRC5;EREG;...
Hippo signaling pathway 1.68 2.16e-2 120/186 (64.52%) AREG;CCN2;BIRC5;...
Apelin signaling pathway 1.65 2.96e-2 117/137 (85.4%) CCN2;GNB1;CCND1;...
Hematopoietic cell lineage 1.64 3.41e-2 90/99 (90.91%) ITGA6;ITGA5;ANPEP;...
Chagas disease 1.64 3.29e-2 93/102 (91.18%) IL1B;CXCL8;PPP2CB;...
ErbB signaling pathway 1.63 3.30e-2 79/85 (92.94%) AREG;EREG;PRKCA;...
Homologous recombination -1.62 3.12e-2 35/41 (85.37%) BLM;RBBP8;RAD51D;...
Peroxisome -1.63 2.97e-2 72/82 (87.8%) PEX1;PAOX;PEX19;...
Protein processing in endoplasmic reticulum -1.64 2.56e-2 127/171 (74.27%) TRAM1;DNAJA2;ERO1B;...
Glycine, serine and threonine metabolism -1.66 2.32e-2 31/40 (77.5%) GRHPR;PSPH;GAMT;...
Fatty acid degradation -1.66 2.37e-2 40/43 (93.02%) ACADM;GCDH;ACSL6;...
Ascorbate and aldarate metabolism -1.71 1.16e-2 15/30 (50%) UGT2B28;UGT2B17;UGDH;...
Base excision repair -1.72 1.18e-2 29/33 (87.88%) APEX2;APEX1;POLE2;...
Arachidonic acid metabolism -1.75 8.94e-3 48/61 (78.69%) CBR1;PTGES;CYP2C9;...
Nucleotide excision repair -1.76 8.45e-3 40/47 (85.11%) POLE3;RPA3;GTF2H3;...
Folate biosynthesis -1.77 8.49e-3 23/26 (88.46%) SPR;MOCOS;AKR1B1;...
Antigen processing and presentation -1.80 6.57e-3 60/78 (76.92%) HLA-DRA;HSPA8;CALR;...
Glycolysis / Gluconeogenesis -1.82 7.17e-3 56/67 (83.58%) AKR1A1;ADH1C;GPI;...
Pentose and glucuronate interconversions -1.82 7.10e-3 17/34 (50%) UGT2B28;DCXR;UGT2B17;...
Glyoxylate and dicarboxylate metabolism -1.89 2.63e-3 23/30 (76.67%) GRHPR;ACO2;MMUT;...
Glutathione metabolism -1.91 1.97e-3 43/57 (75.44%) LAP3;GSTA3;GSTP1;...
Drug metabolism -1.98 0.00e+0 78/151 (51.66%) GSTA3;UGT2B28;CYP3A4;...
Fanconi anemia pathway -1.98 0.00e+0 36/54 (66.67%) RMI1;RAD51;REV1;...
One carbon pool by folate -2.01 0.00e+0 15/20 (75%) SHMT2;ALDH1L1;MTHFD1;...
Mismatch repair -2.07 0.00e+0 22/23 (95.65%) RPA1;RPA2;EXO1;...
Steroid hormone biosynthesis -2.09 0.00e+0 43/61 (70.49%) DHRS11;UGT2B28;CYP3A4;...
DNA replication -2.25 0.00e+0 34/36 (94.44%) POLA1;RFC2;MCM4;...
Metabolism of xenobiotics by cytochrome P450 -2.34 0.00e+0 49/77 (63.64%) GSTA3;CBR1;UGT2B28;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 3.33uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 3.33uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H