Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM0RXBT)

• Drug Name: Beta-carotene Drug Info
• Synonyms: beta-carotene; 7235-40-7; beta Carotene; beta,beta-Carotene; Betacarotene; Provitamin A; Solatene; Carotaben; Provatene; all-trans-beta-Carotene; Serlabo; Natural Yellow 26; Karotin; KPMK; C.I. Food Orange 5; Solatene (caps); Karotin [Czech]; Food orange 5; Zlut prirodni 26; Betacarotenum [Latin]; Betacaroteno [Spanish]; Lucaratin; BetaVit; beta-Karotin; beta-Carotin; beta;-Carotene; beta-Carotene, all-trans-; .beta. Carotene; .beta.-Carotene; Betacarotenum [INN-Latin]; C.I. 75130; Betacaroteno [INN-Spanish]; Zlut prirodni 26 [Czech]
• Cross-matching ID:
  PubChem CID: 5280489
  ChEBI ID: CHEMBL1293
  CAS Number: CAS 7235-40-7
  TTD Drug ID: D0MY8N
  VARIDT Drug ID: DR01414
  INTEDE Drug ID: DR0204

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid hormone biosynthesis	1.86	4.88e-2	43/61 (70.49%)	CYP1B1;AKR1C2;AKR1C3;...
Selenocompound metabolism	1.83	3.26e-2	11/17 (64.71%)	TXNRD1;PAPSS2;SEPHS2
RNA degradation	-1.77	4.80e-2	53/79 (67.09%)	C1D;CNOT4;BTG2;...
DNA replication	-1.82	2.65e-2	34/36 (94.44%)	MCM6;MCM2;POLD1;...
Glycine, serine and threonine metabolism	-1.95	0.00e+0	31/40 (77.5%)	BHMT;PGAM1;GLDC;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	0.66uM - 20uM	3H, 24H	Hide ▲