Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM0SHPY)

• Drug Name: Homovanillic acid Drug Info
• Synonyms: Homovanilic acid; Homovanillate; Homovanillic acid; Homovanillic acid, 98%; Homovanillinic acid; Homovaniuic acid; Vanilacetic acid; Vanillacetic acid; (4-HYDROXY-3-METHOXYPHENYL)ACETIC ACID; 2-(4-hydroxy-3-methoxy-phenyl)acetic acid; 2-(4-hydroxy-3-methoxyphenyl)acetic acid; 3-Methoxy-4-hydroxyphenylacetate; 3-Methoxy-4-hydroxyphenylacetic acid; 306-08-1; 4-Hydroxy-3-methoxybenzeneacetic acid; 4-Hydroxy-3-methoxyphenylacetic acid; Benzeneacetic acid, 4-hydroxy-3-methoxy-; HVA; MFCD00004350; NSC 16682; UNII-X77S6GMS36
• Cross-matching ID:
  PubChem CID: 1738
  ChEBI ID: CHEMBL545959
  CAS Number: CAS 306-08-1
  INTEDE Drug ID: DR2258

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Complement and coagulation cascades	2.06	0.00e+0	76/85 (89.41%)	C4BPA;FGG;C3;...
Oxidative phosphorylation	1.94	7.86e-3	93/133 (69.92%)	ATP6V1D;NDUFA10;ATP6V0A1;...
Cholesterol metabolism	1.90	7.86e-3	44/50 (88%)	VDAC1;LPL;LIPG;...
Collecting duct acid secretion	1.88	5.89e-3	22/27 (81.48%)	ATP6V1D;SLC12A7;ATP6V0A1;...
Fatty acid biosynthesis	1.79	2.99e-2	16/18 (88.89%)	ACSL4;ACSL1;FASN;...
Linoleic acid metabolism	1.76	3.67e-2	21/29 (72.41%)	PLAAT3;CYP2E1;PLA2G4C;...
Circadian rhythm	1.75	3.59e-2	26/31 (83.87%)	CUL1;PER2;RBX1;...
Allograft rejection	-1.83	4.80e-2	32/38 (84.21%)	HLA-A;HLA-DMB;HLA-DOB;...
Antigen processing and presentation	-2.07	0.00e+0	60/78 (76.92%)	HLA-DMB;HLA-DOB;HLA-C;...
Graft-versus-host disease	-2.19	0.00e+0	32/42 (76.19%)	HLA-A;HLA-DMB;HLA-DOB;...
Type I diabetes mellitus	-2.21	0.00e+0	38/43 (88.37%)	HLA-A;HLA-DMB;HLA-DOB;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.04uM - 10uM	24H	Hide ▲