Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM0SXNM)

Drug Name
glycocholic acid Drug Info
Synonyms glycocholate; cholylglycine
Cross-matching ID
PubChem CID
10140
ChEBI ID
CHEMBL411070
CAS Number
CAS 475-31-0
TTD Drug ID
D08WQV
VARIDT Drug ID
DR00569

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Histidine metabolism -1.76 4.41e-2 16/22 (72.73%) ALDH9A1;ALDH3A2;ALDH3B1;...
Ovarian steroidogenesis -1.77 4.82e-2 41/51 (80.39%) FSHB;HSD3B2;CYP19A1;...
Pentose and glucuronate interconversions -1.82 2.39e-2 17/34 (50%) RPE;AKR1A1;UGT2B15;...
Steroid biosynthesis -1.96 4.98e-3 19/20 (95%) MSMO1;CYP24A1;SC5D;...
Ascorbate and aldarate metabolism -1.97 6.64e-3 15/30 (50%) UGT2B17;ALDH9A1;ALDH3A2;...
Ferroptosis -2.13 0.00e+0 36/41 (87.8%) MAP1LC3B;GCLM;SLC39A14;...
Steroid hormone biosynthesis -2.34 0.00e+0 43/61 (70.49%) HSD3B2;CYP19A1;CYP21A2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 4uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H