Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM10XWU)

Drug Name
Atipamezole Drug Info
Synonyms
Atipamezole; 104054-27-5; Antisedan; MPV-1248; MPV 1248; 4-(2-Ethyl-2-indanyl)imidazole; 4-(2-ethyl-2,3-dihydro-1h-inden-2-yl)-1h-imidazole; Atipamezolum [Latin]; Atipamezol [Spanish]; UNII-03N9U5JAF6; 1H-Imidazole, 4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-; 03N9U5JAF6; 5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole; NCGC00182707-01; Zeolite, type: ZSM-5; DSSTox_CID_29061; DSSTox_RID_83274; DSSTox_GSID_49135; 5-(2-ethyl-1,3-dihydroinden-2-yl)-1H-imidazole; antipamezole; Atipamezolum; Atipamezol; C14H16N2
Cross-matching ID
PubChem CID
71310
ChEBI ID
CHEMBL353972
CAS Number
CAS 104054-27-5
TTD Drug ID
D05OVC

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Drug metabolism 2.00 0.00e+0 78/151 (51.66%) CES1;ADH1B;GSTA1;...
Hematopoietic cell lineage 1.94 0.00e+0 90/99 (90.91%) CD59;ANPEP;IL1B;...
Metabolism of xenobiotics by cytochrome P450 1.94 0.00e+0 49/77 (63.64%) CYP1B1;ADH1B;GSTA1;...
Biosynthesis of unsaturated fatty acids 1.86 1.30e-2 21/27 (77.78%) HACD1;ELOVL5;SCD;...
Morphine addiction 1.86 1.04e-2 80/91 (87.91%) GNAI1;GNG11;GABRP;...
Th17 cell differentiation 1.79 2.38e-2 95/107 (88.79%) IL1B;IL27RA;STAT3;...
Propanoate metabolism 1.78 2.23e-2 30/34 (88.24%) DLD;ACAT1;ALDH6A1;...
Phenylalanine metabolism 1.77 2.44e-2 14/17 (82.35%) ALDH3A1;PAH;AOC3;...
Tyrosine metabolism 1.76 2.89e-2 30/36 (83.33%) ADH1B;ALDH3A1;AOC3;...
Dopaminergic synapse 1.75 2.73e-2 115/132 (87.12%) GNAI1;GNG11;PRKCB;...
Primary bile acid biosynthesis 1.75 2.60e-2 15/17 (88.24%) CH25H;SLC27A5;CYP46A1;...
GABAergic synapse 1.74 3.03e-2 76/89 (85.39%) GNAI1;GNG11;GABRP;...
PPAR signaling pathway 1.72 3.60e-2 66/74 (89.19%) FABP7;HMGCS1;FABP1;...
Pyruvate metabolism 1.71 3.34e-2 41/47 (87.23%) ADH1B;DLD;ACAT1;...
Renin secretion 1.71 3.20e-2 61/69 (88.41%) GNAI1;PRKACB;CLCA1;...
Pentose and glucuronate interconversions 1.70 3.00e-2 17/34 (50%) UGT2B28;AKR1B1;UGP2;...
Fat digestion and absorption 1.69 3.06e-2 35/43 (81.4%) ACAT1;FABP1;PLPP3;...
Gap junction 1.68 3.03e-2 72/88 (81.82%) GNAI1;PRKCB;PRKCA;...
beta-Alanine metabolism 1.67 3.28e-2 25/30 (83.33%) ALDH3A1;AOC3;ALDH3A2;...
Circadian entrainment 1.66 3.83e-2 85/97 (87.63%) GNAI1;GNG11;PRKCB;...
Long-term depression 1.65 4.27e-2 55/60 (91.67%) GNAI1;PRKCB;PRKCA;...
Alcoholism 1.64 4.90e-2 86/186 (46.24%) GNAI1;GNG11;FOSB;...
Non-homologous end-joining 1.63 4.97e-2 11/13 (84.62%) DNTT;XRCC5;MRE11;...
Retinol metabolism 1.63 4.87e-2 41/68 (60.29%) DHRS3;ADH1B;UGT2B28;...
Tryptophan metabolism 1.63 4.73e-2 35/42 (83.33%) CYP1B1;KYNU;DLD;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
SK-N-SH CVCL_0531 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H