Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM1237M)

Drug Name
Alfacalcidol Drug Info
Synonyms
Alfacalcidol [INN:BAN:JAN]; Alfacalcidolum; Alfacalcidolum [INN-Latin]; Alfarol; Alpha D 3; Alphacalcidol; Alsiodol; Bondiol; EinsAlpha; One-Alpha; Oxydevit; Sinovul; URQ2517572; Un-Alpha; Vitamin D3, 1alpha-Hydroxy-; alfacalcidol; alpha-Calcidol; (5Z,7E)-9,10-Seco-5,7,10(19)-cholestatrien-1alpha,3beta-diol; 1-Hydroxycholecalciferol; 1-Hydroxyvitamin D3; 1alpha-Hydroxy-vitamin D3; 1alpha-Hydroxycholecalciferol; 1alpha-Hydroxyvitamin D3; 1alpha-OH-D3; 41294-56-8; CCRIS 3341; CHEBI:31186; UNII-URQ2517572
Cross-matching ID
PubChem CID
5282181
ChEBI ID
CHEMBL1601669
CAS Number
CAS 41294-56-8
INTEDE Drug ID
DR0060

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Malaria 2.21 0.00e+0 44/50 (88%) CXCL8;HBB;THBS2;...
ECM-receptor interaction 2.17 0.00e+0 80/88 (90.91%) LAMB1;FN1;SDC4;...
IL-17 signaling pathway 2.04 3.78e-3 84/94 (89.36%) CXCL8;S100A8;NFKBIA;...
Legionellosis 2.02 2.83e-3 51/57 (89.47%) CXCL8;CD14;NFKBIA;...
TNF signaling pathway 2.01 2.27e-3 103/112 (91.96%) NFKBIA;TNFAIP3;VEGFC;...
Complement and coagulation cascades 1.98 1.89e-3 76/85 (89.41%) PLAUR;FGG;F3;...
Pertussis 1.97 1.62e-3 64/76 (84.21%) CXCL8;CD14;IL1A;...
Toll-like receptor signaling pathway 1.97 1.42e-3 94/104 (90.38%) CXCL8;CD14;NFKBIA;...
Ferroptosis 1.97 1.26e-3 36/41 (87.8%) SAT1;HMOX1;CYBB;...
Arachidonic acid metabolism 1.89 4.53e-3 48/61 (78.69%) GPX2;ALOX5;PTGS2;...
Leishmaniasis 1.88 4.12e-3 67/77 (87.01%) NFKBIA;IL1A;CYBB;...
NF-kappa B signaling pathway 1.86 5.67e-3 90/104 (86.54%) CXCL8;CD14;NFKBIA;...
Porphyrin and chlorophyll metabolism 1.81 1.13e-2 23/43 (53.49%) HMOX1;ALAS2;BLVRB;...
Amoebiasis 1.79 1.54e-2 99/102 (97.06%) CXCL8;LAMB1;FN1;...
Rheumatoid arthritis 1.78 1.51e-2 78/93 (83.87%) VEGFA;CXCL8;IL1A;...
Phagosome 1.78 1.49e-2 118/152 (77.63%) CD14;THBS2;CYBB;...
Glycolysis / Gluconeogenesis 1.74 2.60e-2 56/67 (83.58%) PCK2;ENO2;ALDH3A1;...
Shigellosis 1.73 2.58e-2 180/246 (73.17%) CXCL8;CD14;NFKBIA;...
Bladder cancer 1.73 2.57e-2 40/41 (97.56%) VEGFA;CXCL8;HBEGF;...
Epithelial cell signaling in Helicobacter pylori infect... 1.70 3.63e-2 62/70 (88.57%) CXCL8;NFKBIA;HBEGF;...
Salmonella infection 1.69 3.67e-2 198/249 (79.52%) CXCL8;CD14;NFKBIA;...
HIF-1 signaling pathway 1.67 4.23e-2 105/109 (96.33%) VEGFA;HMOX1;ENO2;...
AGE-RAGE signaling pathway in diabetic complications 1.66 4.44e-2 97/100 (97%) VEGFA;CXCL8;FN1;...
Focal adhesion 1.66 4.39e-2 180/201 (89.55%) VEGFA;LAMB1;FN1;...
Proteoglycans in cancer 1.66 4.53e-2 172/205 (83.9%) VEGFA;FN1;SDC4;...
Sulfur metabolism 1.65 4.53e-2 9/10 (90%) SELENBP1;TST;MPST;...
Osteoclast differentiation 1.65 4.37e-2 117/127 (92.13%) NFKBIA;IL1A;JUNB;...
Linoleic acid metabolism 1.63 4.74e-2 21/29 (72.41%) PLA2G2A;ALOX15;CYP2C8;...
Fanconi anemia pathway -1.73 4.68e-2 36/54 (66.67%) FAAP24;RPA2;RAD51C;...
Asthma -1.86 2.85e-2 25/31 (80.65%) IL9;EPX;FCER1A;...
DNA replication -2.02 0.00e+0 34/36 (94.44%) DNA2;MCM7;RFC2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 8uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H