General Information of Drug (ID: DM13VTW)

Drug Name
Flucytosine Drug Info
Synonyms
Alcobon; Ancobon; Ancotil; Ancotyl; Flucitosina; Flucystine; Flucytosin; Flucytosinum; Flucytosone; Fluocytosine; Fluorcytosine; Fluorocytosine; Flucitosina [DCIT]; F0321; LT00771985; Ancobon (TN); Flucytosinum [INN-Latin]; GL663142 & 5FC; Ro 2-9915; Ro 29915 E/265601; Ro-2-9915; Flucytosine (JP15/USP/INN); Flucytosine [USAN:INN:BAN:JAN]; Cytosine, 5-fluoro-(6CI,7CI,8CI); GL663142 & 4-Amino-5-fluoropyrimidin-2(1H)-one; 2(1H)-Pyrimidinone, 4-amino-5-fluoro-); 2-Hydroxy-4-amino-5-fluoropyrimidine; 4-Amino-5-fluoro-2(1H)-pyrimidinone; 4-Amino-5-fluoro-2-hydroxypyrimidine; 4-Amino-5-fluoro-2-hyroxypyrimidine; 4-Amino-5-fluoropyrimidin-2(1H)-one; 5-FC; 5-Flucytosine; 5-Fluorocystosine; 5-Fluorocytosin; 5-Fluorocytosine; 5-Fluorocytosine-6-3H; 5-Flurocytosine; 5-fluoro cytosine; 5987P; 6-Amino-2-oxo-5-fluoropyrimidine; 6-amino-5-fluoro-1H-pyrimidin-2-one; 9074P
Therapeutic ClassAntifungal Agents
Cross-matching ID
PubChem CID
3366
ChEBI ID
CHEMBL1463
CAS Number
CAS 2022-85-7
TTD Drug ID
D0S5WG
INTEDE Drug ID
DR2287
ACDINA Drug ID
D00281

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Ferroptosis 1.67 3.31e-1 36/41 (87.8%) ACSL1;CP;NCOA4;...
Phagosome 1.62 3.54e-1 118/152 (77.63%) SFTPA2;TLR4;ATP6V1D;...
Lysosome 1.61 2.79e-1 115/128 (89.84%) AP1S2;NPC2;CTSE;...
Collecting duct acid secretion 1.60 2.54e-1 22/27 (81.48%) CA2;ATP6V1D;ATP6V1E1;...
Necroptosis 1.60 2.11e-1 113/159 (71.07%) GLUL;TLR4;CHMP5;...
Ribosome 1.59 1.91e-1 113/158 (71.52%) MRPS16;RPL36AL;RPS5;...
Mannose type O-glycan biosynthesis 1.59 1.72e-1 14/23 (60.87%) LARGE1;FUT9;RXYLT1;...
Protein export 1.58 1.63e-1 17/23 (73.91%) SEC61G;SRP9;SPCS1;...
Protein processing in endoplasmic reticulum 1.52 2.72e-1 127/171 (74.27%) HSPA8;SKP1;CALR;...
Synaptic vesicle cycle 1.46 3.77e-1 63/78 (80.77%) SLC1A3;ATP6V1D;SLC1A1;...
Aminoacyl-tRNA biosynthesis 1.46 3.51e-1 15/66 (22.73%) IARS2;QRSL1;GATC;...
Influenza A 1.46 3.29e-1 156/172 (90.7%) NFKBIB;TLR4;OAS2;...
mTOR signaling pathway 1.44 3.61e-1 114/154 (74.03%) ATP6V1D;WNT5A;DVL3;...
Herpes simplex virus 1 infection 1.43 3.43e-1 165/498 (33.13%) OAS2;CALR;BST2;...
Prolactin signaling pathway 1.43 3.37e-1 66/70 (94.29%) CCND2;KRAS;ESR1;...
Mitophagy 1.41 3.49e-1 56/68 (82.35%) BNIP3;BCL2L13;KRAS;...
Leishmaniasis 1.41 3.30e-1 67/77 (87.01%) NFKBIB;TLR4;ITGB1;...
Steroid hormone biosynthesis 1.41 3.13e-1 43/61 (70.49%) AKR1C3;AKR1C1;AKR1C2;...
Nucleotide excision repair 1.41 3.15e-1 40/47 (85.11%) RFC2;RAD23B;POLE2;...
Measles 1.39 3.45e-1 133/139 (95.68%) HSPA8;NFKBIB;TLR4;...
Fanconi anemia pathway 1.39 3.32e-1 36/54 (66.67%) REV1;FAN1;MLH1;...
Renin-angiotensin system 1.38 3.43e-1 20/23 (86.96%) AGT;KLK1;ANPEP;...
Legionellosis 1.37 3.36e-1 51/57 (89.47%) HSPA8;TLR4;CASP7;...
Mismatch repair 1.36 3.47e-1 22/23 (95.65%) RFC2;SSBP1;MLH1;...
Coronavirus disease 1.34 3.81e-1 215/232 (92.67%) NFKBIB;TLR4;OAS2;...
Rheumatoid arthritis 1.34 3.67e-1 78/93 (83.87%) TLR4;ATP6V1D;CD86;...
Endocytosis 1.34 3.57e-1 198/252 (78.57%) HSPA8;EPN2;RAB4A;...
Galactose metabolism 1.33 3.71e-1 26/31 (83.87%) UGP2;PFKM;B4GALT1;...
Hepatitis C 1.33 3.60e-1 139/157 (88.54%) OAS2;CXCL10;KRAS;...
Peroxisome 1.31 3.82e-1 72/82 (87.8%) ACSL1;ACOX2;PXMP4;...
Malaria -1.30 4.44e-1 44/50 (88%) TGFB3;HBB;IFNG;...
Tight junction -1.31 4.15e-1 130/169 (76.92%) PCNA;JAM2;RAC1;...
Synthesis and degradation of ketone bodies -1.31 4.25e-1 9/10 (90%) ACAT1;HMGCS2;BDH1;...
Sulfur relay system -1.32 4.34e-1 5/8 (62.5%) MPST;MOCS3;TST
Glucagon signaling pathway -1.32 4.39e-1 89/107 (83.18%) CREB5;GYS2;PPARGC1A;...
Cellular senescence -1.32 4.47e-1 139/156 (89.1%) MYBL2;HIPK1;HRAS;...
Estrogen signaling pathway -1.34 4.40e-1 119/137 (86.86%) FKBP4;CREB5;HSP90B1;...
Starch and sucrose metabolism -1.36 4.05e-1 25/36 (69.44%) HK2;GYS2;PYGL;...
Transcriptional misregulation in cancer -1.36 3.99e-1 158/192 (82.29%) FLT3;PDGFA;DDIT3;...
cGMP-PKG signaling pathway -1.39 3.40e-1 145/167 (86.83%) ADRA2C;ATP1B4;ATP1A2;...
Cell adhesion molecules -1.42 2.84e-1 118/148 (79.73%) VTCN1;MPZ;ITGAM;...
Arginine biosynthesis -1.43 2.86e-1 17/22 (77.27%) GOT1;CPS1;GOT2;...
Staphylococcus aureus infection -1.43 2.97e-1 72/95 (75.79%) C3AR1;KRT23;SELPLG;...
Complement and coagulation cascades -1.43 3.11e-1 76/85 (89.41%) ITGAM;SERPING1;F10;...
Vascular smooth muscle contraction -1.44 3.23e-1 113/133 (84.96%) PLA2G4C;PRKCQ;PLA2G2A;...
Thyroid hormone synthesis -1.46 2.93e-1 66/75 (88%) ATP1B4;ATP1A2;TG;...
Bladder cancer -1.47 2.90e-1 40/41 (97.56%) CDKN1A;TP53;THBS1;...
Wnt signaling pathway -1.49 2.60e-1 124/166 (74.7%) LRP6;FZD2;RNF43;...
Tyrosine metabolism -1.50 2.68e-1 30/36 (83.33%) TAT;TPO;ADH6;...
Glycine, serine and threonine metabolism -1.52 2.34e-1 31/40 (77.5%) MAOB;MAOA;AOC3;...
Alanine, aspartate and glutamate metabolism -1.53 2.41e-1 27/37 (72.97%) NIT2;GFPT1;CAD;...
Butanoate metabolism -1.53 2.63e-1 23/28 (82.14%) HADH;ACAT1;HMGCS2;...
p53 signaling pathway -1.58 1.94e-1 63/73 (86.3%) SIAH1;CCNE2;CYCS;...
Selenocompound metabolism -1.58 2.19e-1 11/17 (64.71%) PAPSS2;SCLY;TXNRD1;...
Phenylalanine metabolism -1.59 2.43e-1 14/17 (82.35%) TAT;MAOB;MAOA;...
African trypanosomiasis -1.59 2.90e-1 32/37 (86.49%) PLCB2;HBB;IFNG;...
Retinol metabolism -1.60 2.97e-1 41/68 (60.29%) ADH1C;DGAT1;CYP2B6;...
Leukocyte transendothelial migration -1.63 2.97e-1 90/114 (78.95%) ARHGAP5;PLCG2;GNAI3;...
Renin secretion -1.71 1.95e-1 61/69 (88.41%) PLCB2;GNAI3;PPP3R1;...
TGF-beta signaling pathway -1.76 2.41e-1 81/94 (86.17%) TGFB3;IFNG;RBL1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H