Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM14MAE)

• Drug Name: Pergolide Drug Info
• Synonyms: Pergolida; Pergolidum; Permax; Pergolida [INN-Spanish]; Pergolide (INN); Pergolide [INN:BAN]; Pergolidum [INN-Latin]; Permax (TN); LY-127,809; (6aR,9R,10aR)-9-(Methylthiomethyl)-7-propyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline; (8beta)-8-[(methylsulfanyl)methyl]-6-propylergoline; (8beta)-8-[(methylthio)methyl]-6-propylergoline
• Therapeutic Class: Antiparkinson Agents
• Cross-matching ID:
  PubChem CID: 47811
  ChEBI ID: CHEMBL531
  CAS Number: CAS 66104-22-1
  TTD Drug ID: D04JCN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Cell cycle	1.97	1.36e-2	110/124 (88.71%)	CCNB2;SMC1A;CDK6;...
DNA replication	1.96	6.80e-3	34/36 (94.44%)	RPA3;RNASEH2A;POLE2;...
Mismatch repair	1.85	2.27e-2	22/23 (95.65%)	RPA3;POLD2;EXO1;...
Proteasome	1.74	4.93e-2	44/46 (95.65%)	PSMB8;PSMB9;PSMA6;...
Pentose phosphate pathway	-1.79	4.37e-2	25/30 (83.33%)	TKTL1;PGD;ALDOA;...
ErbB signaling pathway	-1.80	4.87e-2	79/85 (92.94%)	EREG;AKT2;GAB1;...
Proximal tubule bicarbonate reclamation	-1.90	1.39e-2	21/23 (91.3%)	PCK1;SLC25A10;GLUD2;...
Arginine and proline metabolism	-1.90	1.74e-2	39/50 (78%)	CKMT2;MAOA;ALDH3A2;...
Gastric acid secretion	-1.91	2.32e-2	63/76 (82.89%)	ITPR2;ADCY9;KCNJ15;...
Galactose metabolism	-1.93	3.48e-2	26/31 (83.87%)	HK2;B4GALT2;PFKP;...
Mineral absorption	-2.73	0.00e+0	48/60 (80%)	MT1M;ATP1A2;CYBRD1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Hide ▲

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	10uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼