Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM14NKM)

Drug Name
Triiodothyronine Drug Info
Synonyms
liothyronine; triiodothyronine; 3,3',5-Triiodo-L-thyronine; 6893-02-3; Liothyronin; Tresitope; 3,5,3'-triiodothyronine; L-Liothyronine; O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine; 3,5,3'-Triiodo-L-thyronine; triothyrone; Liothyroninum; Lyothyronine; Liotironina; T3; L-T3; 3,3',5-Triiodothyronine; Triiodo-L-thyronine; 3,5,3'TRIIODOTHYRONINE; L-3,5,3'-Triiodothyronine; T3 (amino acid); T3 (Hormone); L-3,3',5-TriioDOThyronine; Liothyronine [INN:BAN]; Li; Liothyronine
Cross-matching ID
PubChem CID
5920
ChEBI ID
CHEMBL1544
CAS Number
CAS 15785-49-6
TTD Drug ID
D07NPX

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Protein export 1.94 2.10e-2 17/23 (73.91%) OXA1L;SRP14;SEC62;...
Ribosome 1.81 4.56e-2 113/158 (71.52%) RSL24D1;RPL36;RPL36AL;...
Spliceosome 1.81 3.04e-2 101/150 (67.33%) HSPA8;SRSF7;PQBP1;...
Adipocytokine signaling pathway -1.95 0.00e+0 64/69 (92.75%) JAK2;STK11;ACSL6;...
Complement and coagulation cascades -1.98 0.00e+0 76/85 (89.41%) C1R;PROCR;SERPINA1;...
PPAR signaling pathway -2.14 0.00e+0 66/74 (89.19%) NR1H3;PPARG;RXRB;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H