Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM14X29)

Drug Name
diarylpropionitril Drug Info
Synonyms
1428-67-7; diarylpropionitrile; 2,3-bis(4-hydroxyphenyl)propionitrile; 2,3-bis(4-hydroxyphenyl)propanenitrile; 2,3-bis(4-hydroxyphenyl)-propionitrile; 2,3-Bis(p-hydroxyphenyl)propionitrile; CHEMBL334773; CHEBI:63949; DPN compound; Benzenepropanenitrile,4-hydroxy-a-(4-hydroxyphenyl)-; SR-01000597601; BRN 3337109; SC-4473; 2,3-Bis(p-hydroxyphenyl)-propionitrile; Propionitrile, 2,3-bis(p-hydroxyphenyl); Propionitrile, 2,3-bis(p-hydroxyphenyl)-; AC1L2T6L; GTPL2825; SCHEMBL1940848; DTXSID0040387; CTK8F9375; MolPort-003-983-761
Cross-matching ID
PubChem CID
102614
ChEBI ID
CHEMBL334773
CAS Number
CAS 1428-67-7
TTD Drug ID
D05EOW

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Protein processing in endoplasmic reticulum 2.13 0.00e+0 127/171 (74.27%) HSP90B1;P4HB;HSPA5;...
Primary bile acid biosynthesis -1.70 3.77e-2 15/17 (88.24%) ACOT8;CH25H;CYP27A1;...
Ascorbate and aldarate metabolism -1.75 2.49e-2 15/30 (50%) RGN;AKR1A1;UGT2B17;...
Bile secretion -1.77 2.07e-2 68/90 (75.56%) ABCC4;SCARB1;AQP8;...
Drug metabolism -1.79 1.91e-2 78/151 (51.66%) ADH1B;FMO5;FMO4;...
Tryptophan metabolism -1.80 1.86e-2 35/42 (83.33%) CYP1A1;HADHA;KYNU;...
Metabolism of xenobiotics by cytochrome P450 -1.81 1.79e-2 49/77 (63.64%) ADH6;CYP1A1;CYP2D6;...
Thyroid cancer -1.86 1.03e-2 36/37 (97.3%) DDB2;MAPK3;KRAS;...
Endometrial cancer -1.91 7.97e-3 56/58 (96.55%) BAD;DDB2;CTNNA3;...
Pentose and glucuronate interconversions -1.98 7.18e-3 17/34 (50%) AKR1B10;AKR1A1;CRYL1;...
Steroid hormone biosynthesis -1.99 8.97e-3 43/61 (70.49%) UGT2B17;STS;HSD17B7;...
African trypanosomiasis -2.03 3.99e-3 32/37 (86.49%) FAS;F2RL1;PLCB3;...
Retinol metabolism -2.18 0.00e+0 41/68 (60.29%) ALDH1A1;CYP2C18;RDH11;...
Complement and coagulation cascades -2.22 0.00e+0 76/85 (89.41%) SERPINF2;C8G;ITGAX;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H