General Information of Drug (ID: DM154EB)

Drug Name
Lypressin Drug Info
Synonyms Lysine-vasopressin; Lysine-8-vasopressin
Cross-matching ID
PubChem CID
644076
ChEBI ID
CHEMBL94802
CAS Number
CAS 50-57-7
TTD Drug ID
D09PZZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.05 0.00e+0 34/36 (94.44%) PCNA;POLE3;FEN1;...
Epstein-Barr virus infection 2.01 6.26e-3 189/202 (93.56%) MYC;HLA-B;HLA-F;...
Hematopoietic cell lineage 2.00 4.17e-3 90/99 (90.91%) CD59;CD36;ITGA6;...
Allograft rejection 1.92 1.25e-2 32/38 (84.21%) HLA-B;HLA-F;HLA-DRB1;...
Th1 and Th2 cell differentiation 1.90 1.50e-2 80/92 (86.96%) JAG1;MAF;HLA-DRB1;...
Type I diabetes mellitus 1.89 1.88e-2 38/43 (88.37%) HLA-B;HLA-F;HLA-DRB1;...
TNF signaling pathway 1.86 2.32e-2 103/112 (91.96%) JAG1;MMP9;CXCL1;...
Cellular senescence 1.85 2.19e-2 139/156 (89.1%) MYC;HLA-B;HLA-F;...
Viral carcinogenesis 1.84 2.22e-2 149/203 (73.4%) ACTN1;HDAC9;GSN;...
MicroRNAs in cancer 1.84 2.00e-2 146/310 (47.1%) MMP9;TNC;PRKCB;...
Th17 cell differentiation 1.80 2.50e-2 95/107 (88.79%) HLA-DRB1;IL1RAP;TGFBR2;...
Graft-versus-host disease 1.80 2.29e-2 32/42 (76.19%) HLA-B;HLA-F;HLA-DRB1;...
Rheumatoid arthritis 1.79 2.21e-2 78/93 (83.87%) ATP6V1D;CXCL1;HLA-DRB1;...
Human T-cell leukemia virus 1 infection 1.76 2.32e-2 197/219 (89.95%) MMP7;CDC20;MYC;...
Regulation of lipolysis in adipocytes 1.75 2.17e-2 52/55 (94.55%) PLAAT3;PTGER3;FABP4;...
Ribosome biogenesis in eukaryotes 1.75 2.11e-2 52/108 (48.15%) NOP56;NXT1;GTPBP4;...
Hepatitis B 1.74 2.21e-2 151/162 (93.21%) MMP9;PCNA;PRKCB;...
Human cytomegalovirus infection 1.73 2.43e-2 201/225 (89.33%) PRKCB;MYC;HLA-B;...
NOD-like receptor signaling pathway 1.72 2.37e-2 145/181 (80.11%) CXCL1;GBP1;OAS2;...
Antigen processing and presentation 1.72 2.25e-2 60/78 (76.92%) HLA-B;HLA-F;HLA-DRB1;...
Notch signaling pathway 1.71 2.50e-2 49/59 (83.05%) JAG1;MFNG;HEY2;...
Kaposi sarcoma-associated herpesvirus infection 1.71 2.50e-2 172/193 (89.12%) RCAN1;MYC;HLA-B;...
Non-homologous end-joining 1.71 2.39e-2 11/13 (84.62%) PRKDC;FEN1;DNTT;...
Autoimmune thyroid disease 1.70 2.55e-2 46/53 (86.79%) HLA-B;HLA-F;HLA-DRB1;...
AGE-RAGE signaling pathway in diabetic complications 1.69 2.75e-2 97/100 (97%) PRKCB;TGFBR2;PLCB1;...
Mismatch repair 1.68 2.84e-2 22/23 (95.65%) PCNA;RPA1;RFC3;...
Chemokine signaling pathway 1.67 3.20e-2 163/192 (84.9%) CXCL14;PRKCB;CXCL1;...
Human immunodeficiency virus 1 infection 1.65 3.35e-2 189/212 (89.15%) PRKCB;HLA-B;HLA-F;...
C-type lectin receptor signaling pathway 1.65 3.28e-2 93/104 (89.42%) PTGS2;AKT3;NRAS;...
IL-17 signaling pathway 1.63 3.42e-2 84/94 (89.36%) MMP9;IL17RB;CXCL1;...
Pyruvate metabolism -1.60 4.76e-2 41/47 (87.23%) ALDH7A1;GRHPR;ALDH3A2;...
Alanine, aspartate and glutamate metabolism -1.61 4.71e-2 27/37 (72.97%) GLUD1;CPS1;AGXT;...
beta-Alanine metabolism -1.61 4.95e-2 25/30 (83.33%) HADHA;CNDP2;MLYCD;...
Caffeine metabolism -1.62 4.74e-2 5/6 (83.33%) NAT2;NAT1
Glycine, serine and threonine metabolism -1.66 3.90e-2 31/40 (77.5%) AGXT;SRR;ALDH7A1;...
Ribosome -1.68 3.67e-2 113/158 (71.52%) RPS16;MRPS11;RPL27A;...
Synthesis and degradation of ketone bodies -1.68 4.08e-2 9/10 (90%) ACAT1;HMGCL;HMGCS1;...
Histidine metabolism -1.70 3.20e-2 16/22 (72.73%) ALDH7A1;ALDH3A2;ALDH3B1;...
Metabolism of xenobiotics by cytochrome P450 -1.72 2.97e-2 49/77 (63.64%) MGST2;GSTM3;CYP2D6;...
Primary bile acid biosynthesis -1.73 3.23e-2 15/17 (88.24%) CYP39A1;AKR1C4;ACOT8;...
Steroid biosynthesis -1.82 1.66e-2 19/20 (95%) MSMO1;HSD17B7;CYP51A1;...
Fatty acid degradation -1.84 6.93e-3 40/43 (93.02%) ACOX3;ALDH7A1;ALDH3A2;...
Valine, leucine and isoleucine degradation -1.91 2.31e-3 42/48 (87.5%) ACAD8;AUH;MCCC1;...
Butanoate metabolism -1.98 0.00e+0 23/28 (82.14%) ACAT1;AACS;EHHADH;...
Complement and coagulation cascades -2.19 0.00e+0 76/85 (89.41%) BDKRB1;F10;C8G;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H