General Information of Drug (ID: DM16GUV)

Drug Name
BRL 52537 hydrochloride Drug Info
Synonyms
2-(3,4-Dichlorophenyl)-1-(2-(pyrrolidin-1-ylmethyl)piperidin-1-yl)ethanone hydrochloride; 130497-33-5; 112282-24-3; BRL 52537; AK-57392; (+/-)-1-(3,4-Dichlorophenyl)acetyl-2-(1-pyrrolidinyl)methylpiperidine hydrochloride; 2-(3,4-DICHLOROPHENYL)-1-(2-(PYRROLIDIN-1-YLMETHYL)PIPERIDIN-1-YL)ETHANONE HCL; SR-01000076141; EU-0101141; BRL-52537 hydrochloride; Brl 52537 HCl; MLS002153457; SCHEMBL8435659; CHEMBL1256835; KS-00000FTT; CTK8C4721; DTXSID00462129; MolPort-003-940-484; BCP21081; EBD29079
Cross-matching ID
PubChem CID
11315337
CAS Number
CAS 130497-33-5
TTD Drug ID
D04YNW

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
ECM-receptor interaction 1.79 1.23e-1 80/88 (90.91%) THBS1;LAMB1;ITGA3;...
DNA replication 1.75 1.23e-1 34/36 (94.44%) PCNA;RFC3;MCM3;...
Amoebiasis 1.70 1.44e-1 99/102 (97.06%) PRKCA;GNAS;TGFB2;...
Dilated cardiomyopathy 1.61 2.62e-1 86/96 (89.58%) GNAS;TPM2;TGFB2;...
Hypertrophic cardiomyopathy 1.56 3.02e-1 81/90 (90%) TPM2;TGFB2;ATP2A2;...
Small cell lung cancer 1.55 3.01e-1 90/92 (97.83%) LAMB1;ITGA3;AKT3;...
Proteoglycans in cancer 1.52 3.23e-1 172/205 (83.9%) PRKCA;THBS1;TGFB2;...
Homologous recombination 1.52 2.92e-1 35/41 (85.37%) BRCC3;RAD51C;NBN;...
Non-homologous end-joining 1.50 3.11e-1 11/13 (84.62%) PRKDC;DCLRE1C;FEN1;...
Ribosome biogenesis in eukaryotes 1.49 2.85e-1 52/108 (48.15%) NOP56;HEATR1;GTPBP4;...
Focal adhesion 1.47 3.05e-1 180/201 (89.55%) PRKCA;THBS1;CAV2;...
Hepatitis B 1.46 3.10e-1 151/162 (93.21%) PRKCA;PCNA;EGR2;...
RNA transport 1.44 3.29e-1 128/186 (68.82%) TARDBP;NUP58;NUP62;...
RNA polymerase 1.43 3.41e-1 23/31 (74.19%) POLR2I;POLR1B;POLR2K;...
Spliceosome 1.42 3.41e-1 101/150 (67.33%) DDX42;HSPA8;HSPA1A;...
Human papillomavirus infection 1.42 3.35e-1 284/331 (85.8%) GNAS;THBS1;FOXO1;...
Chagas disease 1.41 3.17e-1 93/102 (91.18%) GNAS;C1QB;TGFB2;...
Ubiquinone and other terpenoid-quinone biosynthesis 1.41 3.11e-1 9/11 (81.82%) COQ2;GGCX;NQO1;...
AGE-RAGE signaling pathway in diabetic complications 1.40 3.20e-1 97/100 (97%) PRKCA;FOXO1;TGFB2;...
Malaria 1.40 3.06e-1 44/50 (88%) THBS1;TGFB2;THBS4;...
Base excision repair 1.38 3.37e-1 29/33 (87.88%) PCNA;PARP2;LIG1;...
NF-kappa B signaling pathway 1.37 3.34e-1 90/104 (86.54%) BCL2A1;RELB;CXCL1;...
Nucleotide excision repair 1.36 3.40e-1 40/47 (85.11%) PCNA;CETN2;GTF2H3;...
Mismatch repair 1.36 3.37e-1 22/23 (95.65%) PCNA;RFC3;LIG1
PI3K-Akt signaling pathway 1.35 3.42e-1 317/354 (89.55%) PRKCA;THBS1;GNG11;...
Mannose type O-glycan biosynthesis 1.33 3.83e-1 14/23 (60.87%) POMT1;FKTN;CHST10;...
Rheumatoid arthritis 1.31 3.87e-1 78/93 (83.87%) TGFB2;ANGPT1;CXCL1;...
Hippo signaling pathway 1.30 3.85e-1 120/186 (64.52%) ID1;TGFB2;RASSF2;...
Toxoplasmosis 1.29 3.87e-1 103/112 (91.96%) TGFB2;LAMB1;HSPA8;...
Parathyroid hormone synthesis, secretion and action 1.28 3.94e-1 98/106 (92.45%) PRKCA;PTHLH;GNAS;...
T cell receptor signaling pathway -1.32 4.12e-1 93/104 (89.42%) PAK3;NFKBIB;BCL10;...
Porphyrin and chlorophyll metabolism -1.32 4.12e-1 23/43 (53.49%) COX15;HMOX2;UGT2B15;...
Synaptic vesicle cycle -1.32 4.12e-1 63/78 (80.77%) SLC1A6;CACNA1B;SLC6A11;...
Bile secretion -1.33 4.19e-1 68/90 (75.56%) SCARB1;HMGCR;SLC5A1;...
Selenocompound metabolism -1.34 3.95e-1 11/17 (64.71%) SCLY;CTH;SEPHS2
Amino sugar and nucleotide sugar metabolism -1.34 4.03e-1 38/48 (79.17%) HEXA;PGM1;GFPT1;...
Glycine, serine and threonine metabolism -1.35 4.04e-1 31/40 (77.5%) PHGDH;GLDC;GATM;...
Graft-versus-host disease -1.35 4.19e-1 32/42 (76.19%) FAS;KLRD1;GZMB;...
D-Glutamine and D-glutamate metabolism -1.39 3.76e-1 5/5 (100%) GLS;GLUD1
Estrogen signaling pathway -1.39 3.71e-1 119/137 (86.86%) KRT19;PIK3CB;GNAQ;...
Glioma -1.39 3.89e-1 67/75 (89.33%) PIK3CB;BAK1;PDGFRB;...
Biosynthesis of unsaturated fatty acids -1.40 3.82e-1 21/27 (77.78%) TECR;SCD5;ACOT7;...
Staphylococcus aureus infection -1.41 3.96e-1 72/95 (75.79%) ITGAL;ITGB2;HLA-DQB1;...
Vitamin digestion and absorption -1.43 3.54e-1 17/24 (70.83%) MMACHC;SLC19A2;LMBRD1;...
Phototransduction -1.46 2.99e-1 21/29 (72.41%) CALML5;CALML4
Central carbon metabolism in cancer -1.47 2.73e-1 67/70 (95.71%) SLC7A5;PFKP;GLS;...
PPAR signaling pathway -1.50 2.44e-1 66/74 (89.19%) DBI;CD36;FABP7;...
Fat digestion and absorption -1.53 1.89e-1 35/43 (81.4%) APOA4;PLPP1;CLPS;...
Protein digestion and absorption -1.54 1.98e-1 78/103 (75.73%) FXYD2;MEP1B;ATP1B1;...
Glycolysis / Gluconeogenesis -1.55 1.86e-1 56/67 (83.58%) MINPP1;ADH6;PKM;...
Histidine metabolism -1.55 2.04e-1 16/22 (72.73%) HNMT;ALDH9A1;HAL;...
Nicotinate and nicotinamide metabolism -1.56 2.18e-1 25/35 (71.43%) SIRT6;SIRT1;ENPP1;...
Arginine biosynthesis -1.58 2.05e-1 17/22 (77.27%) ARG1;GOT2;GLUL;...
Thyroid cancer -1.62 1.59e-1 36/37 (97.3%) GADD45G;TCF7L1;BAK1;...
Peroxisome -1.62 1.73e-1 72/82 (87.8%) PAOX;PIPOX;PEX16;...
Protein processing in endoplasmic reticulum -1.65 1.56e-1 127/171 (74.27%) RPN1;SEC61B;STT3A;...
Renin-angiotensin system -1.65 1.96e-1 20/23 (86.96%) CTSG;AGTR1;ATP6AP2;...
Ascorbate and aldarate metabolism -1.78 5.22e-2 15/30 (50%) RGN;UGT2B15;AKR1A1;...
Nitrogen metabolism -1.78 7.82e-2 16/17 (94.12%) CA14;CA6;GLUD1;...
Arginine and proline metabolism -1.80 1.37e-1 39/50 (78%) PRODH;GATM;CKB;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H