Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM17ONX)

Drug Name
Fexofenadine Drug Info
Synonyms
Carboxyterfenadine; Fexofendine; Terfenadine acid metabolite; Terfenadine carboxylate; F 9427; MDL 16455; Allegra (TN); Fastofen (TN); Fexofenadine (INN); Fexofenadine [INN:BAN]; Telfast (TN); Terfenadine-COOH; Terfenidine carboxylate, MDL 16455; Tilfur (TN); 2-[4-(1-hydroxy-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butyl)phenyl]-2-methylpropanoic acid; 2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]phenyl]-2-methylpropanoic acid; 4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-alpha,alpha-dimethylbenzeneacetic acid
Therapeutic ClassAntiallergic Agents
Cross-matching ID
PubChem CID
3348
ChEBI ID
CHEMBL914
CAS Number
CAS 83799-24-0
TTD Drug ID
D01KPV
VARIDT Drug ID
DR00026
ACDINA Drug ID
D00273

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 2.38 0.00e+0 93/133 (69.92%) ATP5MG;ATP5F1C;COX7B;...
DNA replication 2.32 0.00e+0 34/36 (94.44%) MCM5;POLE2;LIG1;...
Allograft rejection 2.08 0.00e+0 32/38 (84.21%) GZMB;PRF1;HLA-DMB;...
Antigen processing and presentation 2.07 0.00e+0 60/78 (76.92%) HSPA8;CTSS;HSPA6;...
Type I diabetes mellitus 2.00 2.02e-3 38/43 (88.37%) GZMB;PRF1;PTPRN2;...
Ribosome 1.93 5.06e-3 113/158 (71.52%) RPS4Y1;RPS5;MRPS16;...
Neutrophil extracellular trap formation 1.90 8.67e-3 101/189 (53.44%) SRC;AQP9;PIK3R1;...
Propanoate metabolism 1.89 8.85e-3 30/34 (88.24%) DLD;LDHB;SUCLG2;...
Prion disease 1.87 7.87e-3 209/273 (76.56%) HSPA8;C7;PIK3R1;...
Graft-versus-host disease 1.84 1.21e-2 32/42 (76.19%) GZMB;PRF1;KLRD1;...
Tryptophan metabolism 1.84 1.10e-2 35/42 (83.33%) DLD;IDO1;KMO;...
Drug metabolism 1.82 1.26e-2 78/151 (51.66%) NME4;GSTT1;FMO2;...
Huntington disease 1.82 1.17e-2 233/306 (76.14%) DCTN3;ATP5F1C;COX7B;...
Nucleotide excision repair 1.81 1.45e-2 40/47 (85.11%) POLE2;LIG1;MNAT1;...
Systemic lupus erythematosus 1.80 1.35e-2 45/135 (33.33%) C7;FCGR3B;FCGR2A;...
Glyoxylate and dicarboxylate metabolism 1.78 1.64e-2 23/30 (76.67%) DLD;GRHPR;CS;...
Diabetic cardiomyopathy 1.72 2.74e-2 162/203 (79.8%) PIK3R1;CYBB;CYBA;...
Metabolism of xenobiotics by cytochrome P450 1.71 2.70e-2 49/77 (63.64%) HSD11B1;GSTT1;GSTO1;...
Retinol metabolism 1.70 2.82e-2 41/68 (60.29%) ALDH1A2;DHRS9;DHRS3;...
Mismatch repair 1.70 2.68e-2 22/23 (95.65%) LIG1;PCNA;RFC3;...
Proteasome 1.65 4.05e-2 44/46 (95.65%) PSMB9;PSMA3;PSME1;...
Butanoate metabolism 1.64 4.18e-2 23/28 (82.14%) BDH2;ACSM3;ACSM5;...
Cell cycle 1.64 4.09e-2 110/124 (88.71%) CDC45;CCNA2;SKP1;...
Autoimmune thyroid disease 1.62 4.38e-2 46/53 (86.79%) GZMB;PRF1;HLA-DMB;...
Base excision repair 1.61 4.61e-2 29/33 (87.88%) POLE2;LIG1;NEIL3;...
Phagosome 1.60 4.75e-2 118/152 (77.63%) CD14;FCGR3B;CYBB;...
Tyrosine metabolism 1.60 4.65e-2 30/36 (83.33%) TYRP1;GSTZ1;COMT;...
Natural killer cell mediated cytotoxicity 1.60 4.48e-2 99/131 (75.57%) GZMB;PIK3R1;FCGR3B;...
Mineral absorption -2.31 0.00e+0 48/60 (80%) ATP1A1;SLC26A6;ATP7A;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H