Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM1982I)

Drug Name
LDN-57444 Drug Info
Synonyms
668467-91-2; CHEMBL3407553; LDN 57444; (Z)-3-(acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one; C17H11Cl3N2O3; LDN57444; Ubiquitin Thiolesterase L1 Inhibitor; Ubiquitin C-Terminal Esterase L1 Inhibitor; Ubiquitin C-Terminal Hydrolase L1 Inhibitor; SCHEMBL16249746; BDBM65518; AOB1095; EX-A700; 5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime); 2511AH; BDBM50514120; MFCD09037562; ZINC83434034; AKOS025295611; CS-3923; 3-(O-acetyloxime), 5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-Indole-2,3-dione; NCGC00247668-01; AC-32696; AS-56100; HY-18637; SW219408-1; LDN-57444, >=98% (HPLC); [(E)-[5-Chloro-1-[(2,5-dichlorophenyl)methyl]-2-oxoindol-3-ylidene]amino] acetate
Cross-matching ID
PubChem CID
16760696
ChEBI ID
CHEMBL3407553
TTD Drug ID
DCIP24

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Coronavirus disease 2.12 0.00e+0 215/232 (92.67%) MX1;ISG15;OAS2;...
Herpes simplex virus 1 infection 2.01 4.51e-3 165/498 (33.13%) OAS2;OAS1;IFIH1;...
NF-kappa B signaling pathway 1.93 9.01e-3 90/104 (86.54%) CXCL8;BLNK;DDX58;...
Hepatitis C 1.91 9.01e-3 139/157 (88.54%) IFIT1;MX1;OAS2;...
Influenza A 1.90 7.21e-3 156/172 (90.7%) MX1;OAS2;CXCL8;...
Pertussis 1.90 6.01e-3 64/76 (84.21%) CXCL8;CASP7;TICAM1;...
RIG-I-like receptor signaling pathway 1.78 1.67e-2 64/70 (91.43%) ISG15;CXCL8;IFIH1;...
Viral protein interaction with cytokine and cytokine re... 1.74 3.49e-2 84/100 (84%) CX3CR1;CXCL8;CCR2;...
Epstein-Barr virus infection 1.74 3.31e-2 189/202 (93.56%) ISG15;OAS2;OAS1;...
Measles 1.72 3.52e-2 133/139 (95.68%) MX1;OAS2;OAS1;...
Cytosolic DNA-sensing pathway 1.70 3.77e-2 52/63 (82.54%) IRF7;DDX58;IKBKE;...
NOD-like receptor signaling pathway 1.68 4.21e-2 145/181 (80.11%) OAS2;CXCL8;OAS1;...
Spliceosome 1.68 4.09e-2 101/150 (67.33%) PUF60;HNRNPA3;PRPF40A;...
Legionellosis 1.66 4.38e-2 51/57 (89.47%) CXCL8;CASP7;HSPD1;...
Oxidative phosphorylation -1.71 4.14e-2 93/133 (69.92%) ATP4A;ATP6V0A4;ATP5ME;...
Focal adhesion -1.72 4.01e-2 180/201 (89.55%) HRAS;BIRC2;COL4A3;...
Cortisol synthesis and secretion -1.73 3.85e-2 58/65 (89.23%) PDE8A;ITPR2;CYP11A1;...
Other glycan degradation -1.77 2.85e-2 13/18 (72.22%) MANBA;AGA;NEU1;...
Amino sugar and nucleotide sugar metabolism -1.77 3.10e-2 38/48 (79.17%) NPL;CYB5R3;PMM1;...
Mucin type O-glycan biosynthesis -1.78 2.89e-2 20/36 (55.56%) GALNT12;ST6GALNAC2;B3GNT3;...
Starch and sucrose metabolism -1.81 2.82e-2 25/36 (69.44%) G6PC3;GBE1;HK1;...
Biosynthesis of unsaturated fatty acids -1.84 1.63e-2 21/27 (77.78%) ELOVL4;ACOT7;HSD17B12;...
Glycosaminoglycan biosynthesis -1.84 2.17e-2 40/58 (68.97%) B3GAT3;NDST3;CSGALNACT1;...
Lysosome -1.86 2.71e-2 115/128 (89.84%) NAGLU;ACP2;ATP6V0A1;...
Fatty acid elongation -2.05 1.08e-2 19/27 (70.37%) ELOVL4;ACOT7;HSD17B12;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 24H
Colon
Colon carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 TP53(-/-) CVCL_HD97 Homo sapiens 0.04uM - 10uM 24H
HCT 116 CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 (Parent) CVCL_0291 Homo sapiens 0.04uM - 3.33uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 3.33uM 24H