Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM19M05)

Drug Name
ETS-6103 Drug Info
Synonyms Viotra; ETX-6103; Antidepressant/analgesic (depression/pain), e-Therapeutics; Antidepressant/analgesic (depression/pain), e-Therapeutics/ Khandelwal Laboratories
Cross-matching ID
PubChem CID
33741
TTD Drug ID
D0J5HG

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Proteasome 2.23 0.00e+0 44/46 (95.65%) PSMD2;PSMB6;PSMB9;...
RNA polymerase 1.96 4.68e-3 23/31 (74.19%) POLR2L;POLR2I;POLR3K;...
Ribosome biogenesis in eukaryotes 1.94 3.12e-3 52/108 (48.15%) NVL;NHP2;CSNK2B;...
DNA replication 1.91 2.34e-3 34/36 (94.44%) PCNA;POLE2;MCM2;...
Pyrimidine metabolism 1.78 2.99e-2 40/56 (71.43%) TYMS;NME4;CTPS1;...
Ribosome 1.74 4.52e-2 113/158 (71.52%) RPS4Y1;MRPS2;MRPS16;...
Pentose and glucuronate interconversions -1.74 4.37e-2 17/34 (50%) AKR1A1;UGT2B28;XYLB;...
Butanoate metabolism -1.74 4.86e-2 23/28 (82.14%) HMGCL;EHHADH;AACS;...
Steroid biosynthesis -1.80 3.50e-2 19/20 (95%) NSDHL;SOAT2;LIPA;...
PPAR signaling pathway -1.82 3.02e-2 66/74 (89.19%) FADS2;ME1;EHHADH;...
Retinol metabolism -1.82 2.98e-2 41/68 (60.29%) CYP2C18;ADH6;ALDH1A3;...
Peroxisome -1.86 1.33e-2 72/82 (87.8%) PEX1;XDH;DAO;...
Primary bile acid biosynthesis -1.86 1.78e-2 15/17 (88.24%) SLC27A5;BAAT;AKR1D1;...
Metabolism of xenobiotics by cytochrome P450 -1.92 5.33e-3 49/77 (63.64%) GSTO1;CYP1B1;CYP2A6;...
Steroid hormone biosynthesis -2.06 0.00e+0 43/61 (70.49%) CYP1A1;UGT2B28;SULT1E1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 12.5uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H