Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM1AQVE)

Drug Name
DPI-201-106 Drug Info
Synonyms
4-{3-[4-(Diphenylmethyl)piperazin-1-yl]-2-hydroxypropoxy}-1h-indole-2-carbonitrile; Dpi 201-106; 97730-95-5; SDZ-201106; CHEMBL314639; SDZ-201 106 (+/-); 4-{3-[4-(diphenylmethyl)piperazin-1-yl]-2-hydroxypropoxy}-1h-indole-2-carbonitrile; (+-)-4-(3-(4-(Diphenylmethyl)-1-piperazinyl)-2-hydroxypropoxy)-1H-indole-2-carbonitrile; 1H-Indole-2-carbonitrile, 4-(3-(4-(diphenylmethyl)-1-piperazinyl)-2-hydroxypropoxy-, (+-)-; 4(3-(4-Diphenylmethylpiperazine-1-yl)-2-hydroxypropoxy)-1H-indol-2-carbonitrile; CBiol_001886; DPI-201106; 4-(3-(4-benzhydrylpiperazin-1-yl)-2-hydroxypropoxy)-1H-indole-2-carbonitrile
Cross-matching ID
PubChem CID
5190
ChEBI ID
CHEMBL314639
CAS Number
CAS 97730-95-5
TTD Drug ID
D05ZGW

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication -1.64 3.11e-2 34/36 (94.44%) POLE2;POLD3;POLA1;...
Porphyrin and chlorophyll metabolism -1.65 2.76e-2 23/43 (53.49%) CP;BLVRB;BLVRA;...
Alzheimer disease -1.67 2.73e-2 279/369 (75.61%) ADAM17;PSMA3;PSMD1;...
Pathways of neurodegeneration -1.71 2.37e-2 354/475 (74.53%) PSMA3;PSMD1;VDAC3;...
Non-alcoholic fatty liver disease -1.72 2.00e-2 126/155 (81.29%) PPARG;INSR;NDUFB4;...
Ribosome -1.73 1.91e-2 113/158 (71.52%) RPS20;RPL27A;RPL10A;...
Spliceosome -1.83 5.02e-3 101/150 (67.33%) SF3B5;SRSF5;DHX16;...
Legionellosis -1.85 5.52e-3 51/57 (89.47%) NFKBIA;PYCARD;RAB1B;...
Caffeine metabolism -1.85 6.13e-3 5/6 (83.33%) CYP1A2;NAT2;NAT1
Huntington disease -1.90 1.97e-3 233/306 (76.14%) PSMA3;PSMD1;VDAC3;...
Thermogenesis -1.90 2.25e-3 173/232 (74.57%) COX11;ATP5F1A;RPS6KA1;...
Prion disease -1.91 2.63e-3 209/273 (76.56%) PSMA3;PSMD1;VDAC3;...
Mineral absorption -1.92 3.15e-3 48/60 (80%) MT1H;HEPH;ATP1A2;...
Proteasome -2.08 0.00e+0 44/46 (95.65%) PSMB6;PSMA3;PSMD1;...
Amyotrophic lateral sclerosis -2.09 0.00e+0 267/364 (73.35%) PSMA3;PSMD1;NDUFC1;...
Parkinson disease -2.21 0.00e+0 176/249 (70.68%) PSMA3;PSMD1;VDAC3;...
Oxidative phosphorylation -2.38 0.00e+0 93/133 (69.92%) NDUFA8;NDUFV1;ATP5PF;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H