General Information of Drug (ID: DM1AV5R)

Drug Name
DR2313 Drug Info
Cross-matching ID
PubChem CID
135522417
ChEBI ID
CHEMBL483348
CAS Number
CAS 284028-90-6
TTD Drug ID
D0W7XH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.05 0.00e+0 34/36 (94.44%) POLE2;RFC3;DNA2;...
Fanconi anemia pathway 1.97 5.15e-3 36/54 (66.67%) FANCL;CENPX;RMI1;...
Pyrimidine metabolism 1.78 3.43e-2 40/56 (71.43%) DCK;UMPS;DCTPP1;...
Homologous recombination 1.78 2.58e-2 35/41 (85.37%) RAD54B;TOPBP1;RAD51;...
Mismatch repair 1.76 2.47e-2 22/23 (95.65%) RFC3;MSH2;MSH6;...
Pentose and glucuronate interconversions 1.74 2.58e-2 17/34 (50%) UGT2B28;CRYL1;SORD;...
Drug metabolism 1.72 2.50e-2 78/151 (51.66%) UGT2B28;FMO2;MGST3;...
Base excision repair 1.69 3.48e-2 29/33 (87.88%) POLE2;FEN1;NEIL3;...
Ascorbate and aldarate metabolism 1.67 3.61e-2 15/30 (50%) UGT2B28;ALDH3A2;UGDH;...
Glycosaminoglycan degradation -1.67 2.12e-2 19/19 (100%) IDS;HEXB;HGSNAT;...
Protein processing in endoplasmic reticulum -1.68 2.14e-2 127/171 (74.27%) HERPUD1;SEC24A;SSR2;...
Proteoglycans in cancer -1.68 2.16e-2 172/205 (83.9%) COL1A1;KDR;IQGAP1;...
Focal adhesion -1.72 1.82e-2 180/201 (89.55%) COL1A1;KDR;COL9A1;...
Central carbon metabolism in cancer -1.73 1.66e-2 67/70 (95.71%) GLS;TIGAR;MAP2K1;...
MAPK signaling pathway -1.73 1.66e-2 272/294 (92.52%) DUSP6;RASGRP3;STK4;...
PI3K-Akt signaling pathway -1.73 1.73e-2 317/354 (89.55%) RELA;PIK3R2;LAMA2;...
Non-small cell lung cancer -1.75 1.29e-2 70/72 (97.22%) KIF5C;PIK3R2;MAPK1;...
Notch signaling pathway -1.75 1.35e-2 49/59 (83.05%) EP300;ADAM17;ATXN1;...
Parathyroid hormone synthesis, secretion and action -1.75 1.42e-2 98/106 (92.45%) MMP13;CREB3;PDE4C;...
Glioma -1.77 1.49e-2 67/75 (89.33%) CAMK1D;CDKN2A;MAP2K1;...
Glyoxylate and dicarboxylate metabolism -1.77 1.25e-2 23/30 (76.67%) AGXT;CAT;ACO2;...
Pancreatic cancer -1.79 1.07e-2 75/76 (98.68%) TGFBR2;RELA;PIK3R2;...
Relaxin signaling pathway -1.79 1.14e-2 114/129 (88.37%) FOS;COL1A1;RLN1;...
Epithelial cell signaling in Helicobacter pylori infect... -1.80 1.02e-2 62/70 (88.57%) ATP6V0C;MAPK11;RELA;...
Lysosome -1.81 9.91e-3 115/128 (89.84%) DNASE2;CTSF;SLC11A1;...
Rheumatoid arthritis -1.81 8.49e-3 78/93 (83.87%) ICAM1;ATP6V1F;ATP6V1E1;...
Bladder cancer -1.82 8.00e-3 40/41 (97.56%) MAPK1;MDM2;TYMP;...
Chronic myeloid leukemia -1.83 8.67e-3 72/76 (94.74%) TGFBR2;RELA;PIK3R2;...
AGE-RAGE signaling pathway in diabetic complications -1.84 6.75e-3 97/100 (97%) COL1A1;SERPINE1;TGFBR2;...
Arginine biosynthesis -1.86 7.43e-3 17/22 (77.27%) GLS;GLUD2;ASL;...
Phagosome -1.87 4.95e-3 118/152 (77.63%) ATP6V1F;ATP6V1E1;ITGB1;...
Amoebiasis -1.88 3.71e-3 99/102 (97.06%) IL1R1;COL1A1;ACTN4;...
Human papillomavirus infection -1.90 4.25e-3 284/331 (85.8%) NOTCH4;COL1A1;TCF7L2;...
Steroid biosynthesis -1.91 4.95e-3 19/20 (95%) LSS;CYP51A1;FDFT1;...
Hepatocellular carcinoma -1.92 5.94e-3 135/168 (80.36%) CDKN2A;SMARCD3;PBRM1;...
Mitophagy -1.93 7.43e-3 56/68 (82.35%) SQSTM1;SRC;TP53;...
Vibrio cholerae infection -1.96 4.95e-3 44/50 (88%) PDIA4;ATP6V0C;PRKACA;...
ECM-receptor interaction -1.97 7.43e-3 80/88 (90.91%) COL1A1;COL9A1;ITGB6;...
Protein digestion and absorption -2.30 0.00e+0 78/103 (75.73%) MME;COL4A1;COL3A1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.002uM - 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.002uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H