General Information of Drug (ID: DM1B3UM)

Drug Name
GDC-0152 Drug Info
Synonyms GDC 0152; GDC0152
Cross-matching ID
PubChem CID
46940575
ChEBI ID
CHEMBL2063869
CAS Number
CAS 873652-48-3
TTD Drug ID
D07CLV

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
TNF signaling pathway 2.98 0.00e+0 103/112 (91.96%) VCAM1;NFKBIA;BIRC3;...
Viral protein interaction with cytokine and cytokine re... 2.64 0.00e+0 84/100 (84%) CXCL8;CXCL1;CXCL2;...
NF-kappa B signaling pathway 2.62 0.00e+0 90/104 (86.54%) RELB;VCAM1;NFKBIA;...
IL-17 signaling pathway 2.57 0.00e+0 84/94 (89.36%) NFKBIA;CXCL8;MMP1;...
Rheumatoid arthritis 2.51 0.00e+0 78/93 (83.87%) CXCL8;LTB;MMP1;...
Cytokine-cytokine receptor interaction 2.35 0.00e+0 246/295 (83.39%) CXCL8;LTB;IL32;...
Epstein-Barr virus infection 2.31 0.00e+0 189/202 (93.56%) RELB;NFKBIA;TNFAIP3;...
Herpes simplex virus 1 infection 2.25 0.00e+0 165/498 (33.13%) NFKBIA;BIRC3;IKBKE;...
NOD-like receptor signaling pathway 2.23 0.00e+0 145/181 (80.11%) NFKBIA;BIRC3;CXCL8;...
Legionellosis 2.23 0.00e+0 51/57 (89.47%) NFKBIA;HSPA8;CXCL8;...
Th1 and Th2 cell differentiation 2.22 0.00e+0 80/92 (86.96%) NFKBIA;NFKB1;NOTCH2;...
Influenza A 2.19 0.00e+0 156/172 (90.7%) NFKBIA;CXCL8;CXCL10;...
Th17 cell differentiation 2.19 0.00e+0 95/107 (88.79%) NFKBIA;IL27RA;NFKB1;...
Proteasome 2.18 0.00e+0 44/46 (95.65%) PSMC2;PSMA2;PSMD12;...
Human T-cell leukemia virus 1 infection 2.18 0.00e+0 197/219 (89.95%) RELB;NFKBIA;NFKB1;...
C-type lectin receptor signaling pathway 2.17 0.00e+0 93/104 (89.42%) RELB;NFKBIA;IKBKE;...
Antigen processing and presentation 2.16 0.00e+0 60/78 (76.92%) HSPA8;CTSS;TAPBP;...
Measles 2.15 0.00e+0 133/139 (95.68%) NFKBIA;HSPA8;TNFAIP3;...
Toll-like receptor signaling pathway 2.15 0.00e+0 94/104 (90.38%) NFKBIA;CXCL8;CXCL10;...
Lipid and atherosclerosis 2.11 0.00e+0 190/215 (88.37%) VCAM1;NFKBIA;HSPA8;...
Epithelial cell signaling in Helicobacter pylori infect... 2.08 0.00e+0 62/70 (88.57%) NFKBIA;CXCL8;CXCL1;...
Chagas disease 2.08 0.00e+0 93/102 (91.18%) NFKBIA;CXCL8;NFKB1;...
Chemokine signaling pathway 2.06 0.00e+0 163/192 (84.9%) NFKBIA;CXCL8;CXCL1;...
Toxoplasmosis 2.05 0.00e+0 103/112 (91.96%) NFKBIA;BIRC3;HSPA8;...
Necroptosis 2.04 0.00e+0 113/159 (71.07%) BIRC3;TNFAIP3;BIRC2;...
T cell receptor signaling pathway 2.03 0.00e+0 93/104 (89.42%) NFKBIA;NFKB1;PIK3CD;...
Small cell lung cancer 2.03 0.00e+0 90/92 (97.83%) NFKBIA;BIRC3;LAMC2;...
Cytosolic DNA-sensing pathway 1.99 3.88e-4 52/63 (82.54%) NFKBIA;CXCL10;IKBKE;...
Ribosome biogenesis in eukaryotes 1.97 3.75e-4 52/108 (48.15%) GTPBP4;IMP3;PWP2;...
Pertussis 1.96 3.62e-4 64/76 (84.21%) CXCL8;CXCL5;CXCL6;...
Butanoate metabolism -1.59 4.77e-2 23/28 (82.14%) ACAT1;ECHS1;AACS;...
Pantothenate and CoA biosynthesis -1.60 4.65e-2 14/21 (66.67%) PPCS;DPYD;BCAT1;...
Mineral absorption -1.61 4.48e-2 48/60 (80%) SLC5A1;TRPV6;ATP2B4;...
Glycolysis / Gluconeogenesis -1.61 4.57e-2 56/67 (83.58%) LDHC;PDHB;ADH1C;...
Thermogenesis -1.62 4.47e-2 173/232 (74.57%) PRKAA1;SMARCC2;NDUFA6;...
Pentose and glucuronate interconversions -1.63 4.11e-2 17/34 (50%) UGT2B15;UGT2B4;RPE;...
Biosynthesis of unsaturated fatty acids -1.64 4.14e-2 21/27 (77.78%) HSD17B4;SCD;ELOVL4;...
Proximal tubule bicarbonate reclamation -1.65 3.94e-2 21/23 (91.3%) ATP1A1;PCK2;FXYD2;...
Oxidative phosphorylation -1.67 3.37e-2 93/133 (69.92%) ATP6V1F;NDUFA6;COX6A1;...
Platelet activation -1.68 3.47e-2 106/124 (85.48%) GNAQ;GP1BB;F2R;...
Protein digestion and absorption -1.71 2.19e-2 78/103 (75.73%) SLC1A5;XPNPEP2;MME;...
Vascular smooth muscle contraction -1.73 1.65e-2 113/133 (84.96%) MYLK;GUCY1A1;ITPR2;...
Pyruvate metabolism -1.75 1.40e-2 41/47 (87.23%) LDHC;ACACA;PDHB;...
Phenylalanine metabolism -1.76 1.44e-2 14/17 (82.35%) HPD;PAH;AOC3;...
Cardiac muscle contraction -1.80 1.02e-2 64/87 (73.56%) ATP2A2;COX6A1;COX8A;...
Arginine biosynthesis -1.81 1.03e-2 17/22 (77.27%) GLUD2;GLUD1;OTC;...
beta-Alanine metabolism -1.81 1.16e-2 25/30 (83.33%) HIBCH;DPYD;ALDH6A1;...
Steroid hormone biosynthesis -1.81 1.33e-2 43/61 (70.49%) UGT2B15;HSD17B6;CYP3A5;...
Ascorbate and aldarate metabolism -1.87 6.20e-3 15/30 (50%) UGT2B15;ALDH7A1;UGT2B4;...
Metabolism of xenobiotics by cytochrome P450 -1.95 1.86e-3 49/77 (63.64%) SULT2A1;MGST3;AKR7A3;...
Fatty acid degradation -1.97 2.33e-3 40/43 (93.02%) ACSBG1;ECI2;HADHB;...
Steroid biosynthesis -2.01 0.00e+0 19/20 (95%) DHCR7;NSDHL;SQLE;...
Tyrosine metabolism -2.04 0.00e+0 30/36 (83.33%) ADH1C;ADH1A;DDC;...
Retinol metabolism -2.20 0.00e+0 41/68 (60.29%) RETSAT;ADH1C;CYP2C8;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 3.33uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H