Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM1BV7W)

• Drug Name: Aliskiren Drug Info
• Synonyms: Rasilez; SPP 100; Rasilez (TN); Tekturna (TN); Aliskiren (USAN/INN); (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methyl-2-(propan-2-yl)nonanamide; (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-2-propan-2-ylnonanamide; (2S,4S,5S,7S)-N-(2-Carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]octanamide; Octanamide, .delta.-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-.gamma.-hydroxy-4-methoxy-3-(3-methoxypropoxy)-.alpha.,.zeta.-bis(1-methylethyl)-, [.alpha.S-(alpha.R*,.gamma.R*,.delta.R*,.zeta.R*)]
• Therapeutic Class: Antihypertensive Agents
• Cross-matching ID:
  PubChem CID: 5493444
  ChEBI ID: CHEMBL1639
  CAS Number: CAS 173334-57-1
  TTD Drug ID: D03SVX
  VARIDT Drug ID: DR00061
  INTEDE Drug ID: DR0065
  ACDINA Drug ID: D00019

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Circadian rhythm	2.02	0.00e+0	26/31 (83.87%)	CREB1;PRKAG1;PER2;...
Circadian entrainment	2.01	0.00e+0	85/97 (87.63%)	GNAI1;PLCB1;MAPK1;...
DNA replication	1.99	0.00e+0	34/36 (94.44%)	MCM5;POLE3;RNASEH2A;...
Long-term potentiation	1.88	1.81e-2	61/67 (91.04%)	PLCB1;MAPK1;GNAQ;...
Mismatch repair	1.86	2.17e-2	22/23 (95.65%)	RFC4;RPA3;MLH1;...
Nucleotide excision repair	1.85	1.81e-2	40/47 (85.11%)	CUL4B;CETN2;POLE3;...
Amphetamine addiction	1.82	2.07e-2	57/69 (82.61%)	MAOA;PRKACB;CREB1;...
Neutrophil extracellular trap formation	1.81	1.96e-2	101/189 (53.44%)	SRC;PLCB1;MAPK1;...
Cocaine addiction	1.78	2.28e-2	42/49 (85.71%)	GNAI1;MAOA;PRKACB;...
Dopaminergic synapse	1.77	2.90e-2	115/132 (87.12%)	GNAI1;PLCB1;MAOA;...
Melanogenesis	1.72	3.51e-2	74/101 (73.27%)	GNAI1;PLCB1;MAPK1;...
GnRH secretion	1.71	3.73e-2	60/64 (93.75%)	SPP1;PLCB1;MAPK1;...
Cholinergic synapse	1.71	3.44e-2	99/113 (87.61%)	GNAI1;PLCB1;MAPK1;...
Ribosome	1.71	3.28e-2	113/158 (71.52%)	RPS5;MRPS16;RPS4Y1;...
Tryptophan metabolism	1.69	3.38e-2	35/42 (83.33%)	KYNU;MAOA;CYP1B1;...
Fatty acid biosynthesis	1.68	3.62e-2	16/18 (88.89%)	ACSL3;ACACA;HSD17B8;...
Gap junction	1.67	3.91e-2	72/88 (81.82%)	GNAI1;TUBB2A;SRC;...
Cushing syndrome	1.66	3.83e-2	125/155 (80.65%)	GNAI1;PLCB1;MAPK1;...
Vasopressin-regulated water reabsorption	1.66	3.75e-2	40/44 (90.91%)	AQP3;PRKACB;RAB5C;...
Glucagon signaling pathway	1.66	3.56e-2	89/107 (83.18%)	PLCB1;GNAQ;PRKACB;...
Insulin secretion	1.64	4.20e-2	75/86 (87.21%)	PLCB1;SNAP25;GNAQ;...
Alcoholism	1.63	4.61e-2	86/186 (46.24%)	GNAI1;MAOA;MAPK1;...
VEGF signaling pathway	1.62	4.83e-2	50/59 (84.75%)	SRC;MAPK1;PRKCA;...
Cortisol synthesis and secretion	1.61	4.98e-2	58/65 (89.23%)	PLCB1;GNAQ;PRKACB;...
Ascorbate and aldarate metabolism	-2.01	0.00e+0	15/30 (50%)	UGT2B28;ALDH7A1;ALDH1B1;...
Complement and coagulation cascades	-2.10	0.00e+0	76/85 (89.41%)	THBD;KNG1;CPB2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.04uM - 10uM	24H	Show ▼