Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM1CG0J)

• Drug Name: GGTI-298 Drug Info
• Synonyms: GGTI298; GGTI-298; Ggti 298; 180977-44-0; CHEMBL282748; N-4-[2(R)-Amino-3-mercaptopropyl]amino-2-naphthylbenzoyl-(L)-Leucine methyl ester, TFA; (S)-methyl 2-(4-((R)-2-amino-3-mercaptopropylamino)-2-(naphthalen-1-yl)benzamido)-4-methylpentanoate; SCHEMBL4283635; CHEBI:124997; EX-A2390; ZINC1488051; BCP24854; BDBM50076138; AKOS032945065; CS-6098; NCGC00165800-01; HY-100876; BRD-K19669037-019-01-3; 2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-naphthalen-1-yl-benzoylamino]-4-methyl-pentanoic acid (S)-methyl ester
• Cross-matching ID:
  PubChem CID: 9811606
  ChEBI ID: CHEMBL282748
  CAS Number: CAS 180977-44-0
  TTD Drug ID: D0D0WF

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Nitrogen metabolism	1.96	1.22e-2	16/17 (94.12%)	GLUL;CPS1;GLUD1;...
PPAR signaling pathway	1.95	6.08e-3	66/74 (89.19%)	APOA1;PLIN2;APOA2;...
Proximal tubule bicarbonate reclamation	1.95	4.05e-3	21/23 (91.3%)	AQP1;PCK1;SLC4A4;...
Signaling pathways regulating pluripotency of stem cell...	1.86	1.52e-2	110/143 (76.92%)	KRAS;MAPK13;MEIS1;...
Cholesterol metabolism	1.86	1.22e-2	44/50 (88%)	STAR;APOA1;APOA2;...
Nucleotide excision repair	-1.71	3.94e-2	40/47 (85.11%)	POLE;RPA1;XPA;...
DNA replication	-1.73	3.78e-2	34/36 (94.44%)	RPA3;DNA2;PRIM1;...
Systemic lupus erythematosus	-1.74	4.33e-2	45/135 (33.33%)	HLA-DMB;CTSG;FCGR3B;...
Rheumatoid arthritis	-1.80	2.10e-2	78/93 (83.87%)	TEK;CXCL5;HLA-DPA1;...
Primary immunodeficiency	-1.83	7.87e-3	33/38 (86.84%)	AICDA;IL7R;ADA;...
Base excision repair	-1.85	7.87e-3	29/33 (87.88%)	POLE;PARP4;POLB;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H	Hide ▲