Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM1FX74)

Drug Name
Bretylium Drug Info
Synonyms
Bretylum; Bretylium tolsylate; Bretylium tosylate(USAN); N-(2-bromobenzyl)-N,N-dimethylethanaminium; N-ethyl-N,N-dimethyl-2-bromobenzenemethanaminium; Benzenemethanaminium, 2-bromo-N-ethyl-N,N-dimethyl-, salt with 4-methylbenzenesulfonic acid (1:1); (2-bromobenzyl)ethyldimethylaminium; (2-bromophenyl)methyl-ethyl-dimethylazanium; (o-Bromobenzyl)ethyldimethylammonium p-toluenesulfonate; 2-bromo-N-ethyl-N,N-dimethylbenzenemethanaminium
Therapeutic ClassAntiarrhythmic Agents
Cross-matching ID
PubChem CID
2431
ChEBI ID
CHEMBL1199080
CAS Number
CAS 59-41-6
TTD Drug ID
D02YYF
VARIDT Drug ID
DR01325
ACDINA Drug ID
D00890

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.03 1.35e-2 34/36 (94.44%) PCNA;RFC5;MCM2;...
Salivary secretion 2.01 6.74e-3 76/93 (81.72%) CST1;ATP1A1;CST4;...
Mismatch repair 1.89 1.80e-2 22/23 (95.65%) PCNA;MSH6;RFC5;...
Complement and coagulation cascades 1.84 2.36e-2 76/85 (89.41%) SERPINA1;SERPING1;C1R;...
Vitamin digestion and absorption 1.81 3.50e-2 17/24 (70.83%) SLC19A2;SLC5A6;SCARB1;...
Long-term depression 1.79 3.82e-2 55/60 (91.67%) GNA11;IGF1;PRKCB;...
Growth hormone synthesis, secretion and action 1.69 4.94e-2 108/119 (90.76%) GNA11;GHR;PIK3R1;...
Mineral absorption -1.99 5.74e-3 48/60 (80%) VDR;HMOX1;ATP1A2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H