General Information of Drug (ID: DM1HMJ5)

Drug Name
PROSTRATIN Drug Info
Cross-matching ID
PubChem CID
454217
ChEBI ID
CHEMBL170518
CAS Number
CAS 60857-08-1
TTD Drug ID
D04JNZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
TNF signaling pathway 2.69 0.00e+0 103/112 (91.96%) CXCL1;LIF;CCL20;...
Rheumatoid arthritis 2.58 0.00e+0 78/93 (83.87%) CXCL8;MMP1;CXCL1;...
Legionellosis 2.48 0.00e+0 51/57 (89.47%) CXCL8;CXCL1;CXCL2;...
Malaria 2.39 0.00e+0 44/50 (88%) CXCL8;IL6;ICAM1;...
Cytokine-cytokine receptor interaction 2.37 0.00e+0 246/295 (83.39%) CXCL8;CXCL1;LIF;...
Epithelial cell signaling in Helicobacter pylori infect... 2.34 0.00e+0 62/70 (88.57%) CXCL8;CXCL1;CXCL2;...
Viral protein interaction with cytokine and cytokine re... 2.32 0.00e+0 84/100 (84%) CXCL8;CXCL1;TNFSF10;...
ECM-receptor interaction 2.31 0.00e+0 80/88 (90.91%) LAMC2;SPP1;ITGB5;...
Focal adhesion 2.30 0.00e+0 180/201 (89.55%) LAMC2;SPP1;ITGB5;...
NF-kappa B signaling pathway 2.27 0.00e+0 90/104 (86.54%) CXCL8;CXCL1;PLAU;...
Salmonella infection 2.26 0.00e+0 198/249 (79.52%) CXCL8;TNFSF10;IL6;...
NOD-like receptor signaling pathway 2.24 0.00e+0 145/181 (80.11%) CXCL8;CXCL1;CXCL2;...
Phagosome 2.23 0.00e+0 118/152 (77.63%) ITGB5;NCF2;ITGAM;...
Natural killer cell mediated cytotoxicity 2.20 0.00e+0 99/131 (75.57%) TNFSF10;ICAM1;TNFRSF10B;...
Yersinia infection 2.19 0.00e+0 120/137 (87.59%) CXCL8;IL6;ARPC1B;...
Pathogenic Escherichia coli infection 2.19 0.00e+0 152/197 (77.16%) CXCL8;TNFSF10;IL6;...
Shigellosis 2.14 0.00e+0 180/246 (73.17%) CXCL8;ACTN1;TNIP1;...
Human papillomavirus infection 2.13 0.00e+0 284/331 (85.8%) LAMC2;SPP1;ITGB5;...
Amoebiasis 2.13 0.00e+0 99/102 (97.06%) CXCL8;CXCL1;LAMC2;...
T cell receptor signaling pathway 2.12 0.00e+0 93/104 (89.42%) NFKB1;CDC42;NFKBIA;...
Chagas disease 2.11 0.00e+0 93/102 (91.18%) CXCL8;IL6;GNAS;...
Toxoplasmosis 2.11 0.00e+0 103/112 (91.96%) LAMC2;LAMB3;BIRC3;...
Hematopoietic cell lineage 2.09 0.00e+0 90/99 (90.91%) CD55;CD9;IL6;...
AGE-RAGE signaling pathway in diabetic complications 2.09 0.00e+0 97/100 (97%) CXCL8;EGR1;IL6;...
Osteoclast differentiation 2.08 0.00e+0 117/127 (92.13%) FOSL1;RELB;NCF2;...
Small cell lung cancer 2.07 0.00e+0 90/92 (97.83%) LAMC2;LAMB3;COL4A5;...
Pertussis 2.07 0.00e+0 64/76 (84.21%) CXCL8;IL6;CXCL5;...
HIF-1 signaling pathway 2.06 0.00e+0 105/109 (96.33%) IL6;PFKFB3;TIMP1;...
PI3K-Akt signaling pathway 2.05 0.00e+0 317/354 (89.55%) LAMC2;AREG;SPP1;...
Bladder cancer 2.05 0.00e+0 40/41 (97.56%) CXCL8;MMP1;MMP9;...
Citrate cycle (TCA cycle) -1.61 2.27e-2 30/30 (100%) SDHA;MDH2;SUCLG1;...
Propanoate metabolism -1.63 2.03e-2 30/34 (88.24%) ACADS;HIBCH;MLYCD;...
Synthesis and degradation of ketone bodies -1.63 2.07e-2 9/10 (90%) HMGCL;ACAT1;ACAT2;...
Fat digestion and absorption -1.64 1.90e-2 35/43 (81.4%) NPC1L1;AGPAT1;ACAT1;...
Bile secretion -1.65 1.78e-2 68/90 (75.56%) RXRA;ATP1B2;AQP8;...
Histidine metabolism -1.66 1.65e-2 16/22 (72.73%) MAOB;ALDH3B1;ALDH1B1;...
beta-Alanine metabolism -1.68 1.40e-2 25/30 (83.33%) ALDH3B1;ACADS;HIBCH;...
Primary bile acid biosynthesis -1.69 1.39e-2 15/17 (88.24%) AMACR;ACOT8;CYP46A1;...
Ascorbate and aldarate metabolism -1.80 3.82e-3 15/30 (50%) UGT2A3;ALDH9A1;ALDH7A1;...
Pentose and glucuronate interconversions -1.87 2.40e-3 17/34 (50%) AKR1B1;CRYL1;RPE;...
Pyruvate metabolism -1.90 1.68e-3 41/47 (87.23%) ACACB;MDH2;ME1;...
DNA replication -1.93 1.33e-3 34/36 (94.44%) MCM6;PRIM2;MCM4;...
Peroxisome -1.95 4.66e-4 72/82 (87.8%) ECI2;ACOT8;SOD1;...
Arginine biosynthesis -1.97 4.94e-4 17/22 (77.27%) GLS2;GOT1;CPS1;...
Linoleic acid metabolism -1.98 5.25e-4 21/29 (72.41%) CYP2C19;PLA2G4A;PLA2G12A;...
Fanconi anemia pathway -2.04 5.60e-4 36/54 (66.67%) BRIP1;PALB2;RPA3;...
Cysteine and methionine metabolism -2.08 6.00e-4 43/50 (86%) GCLC;MPST;TST;...
Drug metabolism -2.09 6.46e-4 78/151 (51.66%) DPYS;FMO4;GSTA4;...
Butanoate metabolism -2.09 7.00e-4 23/28 (82.14%) HMGCL;ACAT1;ACAT2;...
Fatty acid degradation -2.11 7.63e-4 40/43 (93.02%) ALDH9A1;ACAT1;HADHB;...
Ribosome -2.14 8.39e-4 113/158 (71.52%) RPS3;RPS10;RPL32;...
Valine, leucine and isoleucine degradation -2.17 0.00e+0 42/48 (87.5%) PCCA;BCKDHB;BCKDHA;...
Tryptophan metabolism -2.18 0.00e+0 35/42 (83.33%) AOC1;ALDH9A1;ACAT1;...
Glycine, serine and threonine metabolism -2.21 0.00e+0 31/40 (77.5%) SHMT1;ALDH7A1;AGXT;...
Alanine, aspartate and glutamate metabolism -2.24 0.00e+0 27/37 (72.97%) ALDH4A1;AGXT;ALDH5A1;...
Retinol metabolism -2.38 0.00e+0 41/68 (60.29%) CYP2C18;ADH6;ADH5;...
Glyoxylate and dicarboxylate metabolism -2.39 0.00e+0 23/30 (76.67%) MDH2;PCCA;ACAT1;...
Tyrosine metabolism -2.42 0.00e+0 30/36 (83.33%) COMT;FAH;DCT;...
Steroid hormone biosynthesis -2.48 0.00e+0 43/61 (70.49%) AKR1D1;COMT;HSD17B2;...
Metabolism of xenobiotics by cytochrome P450 -2.52 0.00e+0 49/77 (63.64%) GSTA4;CYP2D6;ADH6;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Peripheral blood
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H