Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM1LGKP)

Drug Name
Mevastatin Drug Info
Synonyms
Mevastatin; compactin; 73573-88-3; ML-236B; Mevastatinum; Mevastatine; Mevastatina; Mevastatinum [INN-Latin]; Antibiotic ML 236B; Mevastatin [INN]; CS 500; Compactin (penicillium); Mevastatine [INN-French]; UNII-1UQM1K0W9X; ML 236 B; Mevastatina [INN-Spanish]; CCRIS 4505; 1UQM1K0W9X; CHEMBL54440; CHEBI:34848; [(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate; Mevastatin (Compactin); ML236B
Cross-matching ID
PubChem CID
64715
ChEBI ID
CHEMBL54440
CAS Number
CAS 73573-88-3
TTD Drug ID
D0J9GD
INTEDE Drug ID
DR2217

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.33 0.00e+0 19/20 (95%) NSDHL;SQLE;SC5D;...
Cholesterol metabolism 1.83 4.24e-2 44/50 (88%) LDLR;APOA1;NPC1;...
Homologous recombination -1.60 4.41e-2 35/41 (85.37%) BRCA1;RAD51B;RAD52;...
RNA transport -1.63 3.55e-2 128/186 (68.82%) GEMIN8;ELAC1;SUMO1;...
Epstein-Barr virus infection -1.63 3.74e-2 189/202 (93.56%) PSMC2;BAK1;SEM1;...
Cytosolic DNA-sensing pathway -1.63 3.95e-2 52/63 (82.54%) IL6;POLR1D;POLR3C;...
Fanconi anemia pathway -1.65 3.24e-2 36/54 (66.67%) RAD51C;FAAP100;FANCL;...
Nucleotide excision repair -1.67 3.04e-2 40/47 (85.11%) LIG1;XPA;GTF2H1;...
TNF signaling pathway -1.69 2.74e-2 103/112 (91.96%) TRAF1;SELE;EDN1;...
Purine metabolism -1.74 2.07e-2 102/129 (79.07%) ADA2;ADA;NME7;...
Non-homologous end-joining -1.76 1.51e-2 11/13 (84.62%) NHEJ1;DCLRE1C;FEN1;...
Cell cycle -1.78 1.56e-2 110/124 (88.71%) MCM6;WEE1;PKMYT1;...
Mismatch repair -1.84 1.02e-2 22/23 (95.65%) POLD1;SSBP1;MSH2;...
One carbon pool by folate -1.87 6.54e-3 15/20 (75%) MTHFD2L;MTHFS;DHFR;...
Pyrimidine metabolism -1.87 7.27e-3 40/56 (71.43%) NME7;ENTPD6;ENTPD3;...
Cysteine and methionine metabolism -1.88 7.01e-3 43/50 (86%) PHGDH;KYAT3;GCLM;...
Basal transcription factors -1.89 8.01e-3 37/45 (82.22%) TAF5;ERCC2;TAF9B;...
Ribosome -1.90 4.67e-3 113/158 (71.52%) RPL19;RPS25;MRPS18C;...
Alanine, aspartate and glutamate metabolism -1.95 1.87e-3 27/37 (72.97%) AGXT;DDO;ASNS;...
RNA polymerase -1.97 0.00e+0 23/31 (74.19%) POLR1D;POLR3C;POLR2D;...
Proteasome -2.03 0.00e+0 44/46 (95.65%) PSMB2;PSMC5;PSMD9;...
DNA replication -2.04 0.00e+0 34/36 (94.44%) LIG1;MCM5;MCM2;...
Ribosome biogenesis in eukaryotes -2.28 0.00e+0 52/108 (48.15%) GNL3L;MPHOSPH10;LSG1;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.05uM - 4uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.05uM - 10uM 6H, 24H, 48H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 8uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.05uM - 10uM 6H, 24H, 48H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H