Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM1M0Q4)

Drug Name
Procaterol Drug Info
Synonyms
Meptin; Procaterolo; Procaterolum; Procaterol Monohydrochloride; Procaterolo [DCIT]; Procaterolum [Latin]; Meptin (TN); OPC-2009; Procaterol (INN); Procaterol [INN:BAN]; Procaterolum [INN-Latin]; (R*,S*)-(+-)-8-Hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl)-2(1H)-quinolinone; 5-[1-hydroxy-2-(propan-2-ylamino)butyl]quinoline-2,8-diol; 8-Hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl)-2(1H)-quinolinone; 8-hydroxy-5-[1-hydroxy-2-(propan-2-ylamino)butyl]-1H-quinolin-2-one
Therapeutic ClassBronchodilator Agents
Cross-matching ID
PubChem CID
4916
ChEBI ID
CHEMBL160519
CAS Number
CAS 60443-17-6
TTD Drug ID
D0Z1WA
VARIDT Drug ID
DR01436

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.24 0.00e+0 34/36 (94.44%) PCNA;FEN1;POLE2;...
Base excision repair 2.06 0.00e+0 29/33 (87.88%) PCNA;FEN1;POLE2;...
Spliceosome 2.04 0.00e+0 101/150 (67.33%) DDX46;TCERG1;SRSF7;...
Proteasome 1.85 1.50e-2 44/46 (95.65%) PSMD6;PSMA2;PSMD1;...
Retinol metabolism 1.84 1.20e-2 41/68 (60.29%) ALDH1A3;UGT2B28;CYP26B1;...
Mismatch repair 1.81 1.38e-2 22/23 (95.65%) PCNA;MSH6;RPA1;...
Fanconi anemia pathway 1.80 1.18e-2 36/54 (66.67%) FANCL;REV3L;REV1;...
Steroid hormone biosynthesis 1.79 1.41e-2 43/61 (70.49%) CYP1B1;AKR1C2;HSD11B1;...
Cell cycle 1.73 2.50e-2 110/124 (88.71%) DBF4;PCNA;SMC1A;...
Ribosome biogenesis in eukaryotes 1.71 2.93e-2 52/108 (48.15%) RCL1;IMP3;POP7;...
Metabolism of xenobiotics by cytochrome P450 1.70 3.07e-2 49/77 (63.64%) CYP1B1;HSD11B1;AKR1C1;...
Homologous recombination 1.69 3.25e-2 35/41 (85.37%) RPA1;SSBP1;TOPBP1;...
Fatty acid biosynthesis 1.65 4.04e-2 16/18 (88.89%) ACSL1;CBR4;ACSL5
Drug metabolism 1.65 3.75e-2 78/151 (51.66%) RRM2;MPO;UGT2B28;...
Tryptophan metabolism 1.61 4.70e-2 35/42 (83.33%) TDO2;CYP1B1;DLD;...
Salivary secretion -1.62 4.41e-2 76/93 (81.72%) ADCY8;GNAQ;ADRB2;...
MAPK signaling pathway -1.63 4.01e-2 272/294 (92.52%) MAP3K3;FGF5;FGF4;...
Yersinia infection -1.63 4.02e-2 120/137 (87.59%) PIK3CB;ARPC1B;NFKB1;...
SNARE interactions in vesicular transport -1.64 3.89e-2 19/33 (57.58%) STX1A;STX8;SNAP23;...
Fluid shear stress and atherosclerosis -1.65 3.47e-2 123/139 (88.49%) CAV2;PIK3CB;GSTM4;...
Bacterial invasion of epithelial cells -1.66 3.46e-2 59/77 (76.62%) CAV2;PIK3CB;ARPC1B;...
Hepatitis C -1.67 2.88e-2 139/157 (88.54%) NRAS;MAPK1;IFNA17;...
Cell adhesion molecules -1.69 2.63e-2 118/148 (79.73%) ITGB2;SDC1;CNTN2;...
NF-kappa B signaling pathway -1.70 2.25e-2 90/104 (86.54%) NFKB2;BCL2A1;NFKB1;...
Terpenoid backbone biosynthesis -1.70 2.18e-2 18/22 (81.82%) FNTB;MVK;HMGCR;...
Hematopoietic cell lineage -1.70 2.29e-2 90/99 (90.91%) CSF2RA;IL4R;CD1B;...
Rheumatoid arthritis -1.72 2.15e-2 78/93 (83.87%) CXCL3;TNFRSF11A;HLA-DOA;...
Necroptosis -1.74 2.13e-2 113/159 (71.07%) PPID;CYLD;CYBB;...
B cell receptor signaling pathway -1.77 1.82e-2 71/81 (87.65%) CD19;NRAS;MAPK1;...
C-type lectin receptor signaling pathway -1.78 1.39e-2 93/104 (89.42%) BCL3;MRAS;RELA;...
Endocytosis -1.80 1.24e-2 198/252 (78.57%) CBLC;IST1;KIF5A;...
ErbB signaling pathway -1.82 1.24e-2 79/85 (92.94%) PTK2;ABL2;PAK4;...
Neurotrophin signaling pathway -1.82 1.33e-2 107/119 (89.92%) IRAK1;RHOA;NRAS;...
Tuberculosis -1.84 1.13e-2 159/180 (88.33%) ITGB2;CAMK2A;IRAK1;...
Pathogenic Escherichia coli infection -1.86 1.01e-2 152/197 (77.16%) CYTH2;IRAK1;RHOA;...
Vibrio cholerae infection -1.87 9.89e-3 44/50 (88%) TCIRG1;ATP6V0E1;ATP6V1C1;...
NOD-like receptor signaling pathway -1.91 8.24e-3 145/181 (80.11%) ATG12;TAB1;CYBB;...
Shigellosis -1.93 6.18e-3 180/246 (73.17%) HK3;ATG14;PIK3CB;...
HIF-1 signaling pathway -1.96 7.06e-3 105/109 (96.33%) PDHB;IL6R;HK1;...
Salmonella infection -1.97 8.24e-3 198/249 (79.52%) TAB1;KIF5A;CDC42;...
Epithelial cell signaling in Helicobacter pylori infect... -2.05 0.00e+0 62/70 (88.57%) ATP6V1E1;JAM3;NFKB1;...
Mitophagy -2.09 0.00e+0 56/68 (82.35%) TBC1D15;GABARAPL1;CSNK2A2;...
Steroid biosynthesis -2.15 0.00e+0 19/20 (95%) EBP;NSDHL;LIPA;...
Osteoclast differentiation -2.22 0.00e+0 117/127 (92.13%) MAPK1;TNFRSF11A;IL1A;...
Lysosome -2.24 0.00e+0 115/128 (89.84%) CD63;NAGPA;CTSV;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 0.12uM - 10uM 24H
TC-32 CVCL_7141 Homo sapiens 0.12uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-251 MG CVCL_0021 Homo sapiens 0.12uM - 10uM 24H
YH-13 CVCL_1800 Homo sapiens 0.12uM - 10uM 24H
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 0.12uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
MDA-MB-468 CVCL_0419 Homo sapiens 0.12uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 0.12uM - 10uM 24H
T-47D CVCL_0553 Homo sapiens 0.12uM - 10uM 24H
ZR-75-1 CVCL_0588 Homo sapiens 0.12uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GP2d CVCL_1234 Homo sapiens 0.12uM - 10uM 24H
HT-29 CVCL_0320 Homo sapiens 0.12uM - 10uM 6H, 24H
SNU-407 CVCL_5004 Homo sapiens 0.12uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WA09 (H9) Derived CVCL_9773 (WA09) Homo sapiens 0.12uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.12uM - 10uM 24H
HEC-151 CVCL_2927 Homo sapiens 0.12uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 0.12uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 0.12uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 0.12uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 0.12uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Renal cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RCC10RGB CVCL_1656 Homo sapiens 0.12uM - 10uM 24H
Rhabdoid tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
G-401 CVCL_0270 Homo sapiens 0.12uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 12uM 72H
JHH-5 CVCL_1320 Homo sapiens 0.12uM - 10uM 24H
JHH-7 CVCL_1322 Homo sapiens 0.12uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
NCI-H1437 CVCL_1472 Homo sapiens 0.12uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 0.12uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 0.12uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 0.12uM - 10uM 24H
HCC1588 CVCL_1263 Homo sapiens 0.12uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 0.12uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2110 CVCL_1529 Homo sapiens 0.12uM - 10uM 24H
NCI-H2172 CVCL_1534 Homo sapiens 0.12uM - 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H841 CVCL_1595 Homo sapiens 0.12uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 0.12uM - 10uM 24H
Oral cavity
Oral squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BICR 6 CVCL_1086 Homo sapiens 0.12uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVK18 CVCL_1629 Homo sapiens 0.12uM - 10uM 24H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ES-2 CVCL_3509 Homo sapiens 0.12uM - 10uM 24H
OVTOKO CVCL_3114 Homo sapiens 0.12uM - 10uM 24H
Ovarian cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OAW 28 CVCL_1611 Homo sapiens 1.11uM - 10uM 24H
OC 316 CVCL_1615 Homo sapiens 0.12uM - 10uM 24H
Ovarian endometrioid carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TOV-112D CVCL_3612 Homo sapiens 0.12uM - 10uM 24H
Ovarian granulosa cell tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV434 CVCL_2010 Homo sapiens 0.12uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.12uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 0.12uM - 10uM 24H
LNCaP clone FGC CVCL_1379 Homo sapiens 0.12uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.12uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.12uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 0.12uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 0.12uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 0.12uM - 10uM 24H
SK-MEL-3 CVCL_0525 Homo sapiens 0.12uM - 10uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.12uM - 10uM 24H
MKN45 CVCL_0434 Homo sapiens 0.12uM - 10uM 24H
Gastric carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IM95 CVCL_1305 Homo sapiens 0.12uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 0.12uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 0.12uM - 10uM 24H