Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM1MBYQ)

• Drug Name: Ganciclovir Drug Info
• Synonyms: ganciclovir; 82410-32-0; Gancyclovir; Cytovene; Vitrasert; Hydroxyacyclovir; Ganciclovirum; Zirgan; RS-21592; Cymevene; HHEMG; Biolf 62; BW-759U; Ganciclovirum [Latin]; 2'-NDG; 2-Amino-9-(((1,3-dihydroxypropan-2-yl)oxy)methyl)-1H-purin-6(9H)-one; BW 759U; BIOLF-62; 2'-Nor-2'-deoxyguanosine; 9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine; BW-B 759U; UNII-P9G3CKZ4P5; DRG-0018; BW 759; 9-(1,3-DIHYDROXY-PROPOXYMETHANE)GUANINE; 2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6,9-dihydro-3H-purin-6-one; CCRIS 9212; GA2; Cytovene-IV; HSDB 6512
• Therapeutic Class: Antiviral Agents
• Cross-matching ID:
  PubChem CID: 135398740
  ChEBI ID: CHEMBL182
  CAS Number: CAS 82410-32-0
  TTD Drug ID: D05ARP
  VARIDT Drug ID: DR00027
  ACDINA Drug ID: D00298

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.08	0.00e+0	34/36 (94.44%)	PCNA;MCM6;PRIM1;...
Ribosome	1.95	6.71e-3	113/158 (71.52%)	MRPL15;MRPS16;MRPS12;...
Citrate cycle (TCA cycle)	1.75	4.48e-2	30/30 (100%)	IDH3A;DLST;MDH1;...
Non-small cell lung cancer	-1.68	4.92e-2	70/72 (97.22%)	STAT5A;MAP2K1;RXRB;...
Phagosome	-1.71	4.16e-2	118/152 (77.63%)	DYNC1H1;SFTPA2;THBS4;...
Glycine, serine and threonine metabolism	-1.72	3.84e-2	31/40 (77.5%)	BHMT;BPGM;GAMT;...
Leishmaniasis	-1.72	4.09e-2	67/77 (87.01%)	TAB2;PRKCB;IL1A;...
Melanoma	-1.74	3.98e-2	68/72 (94.44%)	FGF3;FGF1;FGF2;...
Ferroptosis	-1.75	4.48e-2	36/41 (87.8%)	SLC3A2;MAP1LC3C;CP;...
Bladder cancer	-1.80	1.83e-2	40/41 (97.56%)	RASSF1;EGFR;E2F3;...
Legionellosis	-1.80	2.13e-2	51/57 (89.47%)	PYCARD;RAB1B;TLR5;...
Fatty acid degradation	-1.84	1.53e-2	40/43 (93.02%)	ECHS1;ALDH9A1;ADH1A;...
Graft-versus-host disease	-1.93	3.20e-3	32/42 (76.19%)	KIR3DL1;KIR2DL3;KIR2DL1;...
Histidine metabolism	-1.97	4.26e-3	16/22 (72.73%)	ALDH9A1;CNDP2;ALDH3A1;...
Complement and coagulation cascades	-2.42	0.00e+0	76/85 (89.41%)	SERPINC1;ITGAX;C1S;...
Staphylococcus aureus infection	-2.46	0.00e+0	72/95 (75.79%)	C2;KRT9;DSG1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	12.5uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼