Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM1N62C)

• Drug Name: Quetiapine Drug Info
• Synonyms: quetiapine; 111974-69-7; Quetiapine [INN:BAN]; UNII-BGL0JSY5SI; BGL0JSY5SI; CHEMBL716; 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol; CHEBI:8707; C21H25N3O2S; URKOMYMAXPYINW-UHFFFAOYSA-N; 2-(2-(4-Dibenzo(b,f)(1,4)thiazepin-11-yl-1-piperazinyl)ethoxy)ethanol; Ethanol, 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-; NCGC00095911-03; Co-Quetiapine; Norsic; Quetiapina; Quetiapinum; Quetiapine hemifumarate; Ketipinor (TN); Norsic (TN); Quetiapine (INN); Seroquel (Fumarate); Seroquel (TN); 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-ylpiperazin-1-yl)ethoxy]ethanol; 2-{[2-(4-dibenzo[b,f][1,4]thiazepin-11-ylpiperazin-1-yl)ethyl]oxy}ethanol; PD-172760
• Therapeutic Class: Antipsychotic Agents
• Cross-matching ID:
  PubChem CID: 5002
  ChEBI ID: CHEMBL716
  CAS Number: CAS 111974-69-7
  TTD Drug ID: D0H7KF
  VARIDT Drug ID: DR00855
  INTEDE Drug ID: DR1376
  ACDINA Drug ID: D00575

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.30	0.00e+0	34/36 (94.44%)	MCM6;RPA2;POLE2;...
Cell cycle	2.04	0.00e+0	110/124 (88.71%)	CDC20;CCNB2;CCNA2;...
Steroid biosynthesis	1.84	1.74e-2	19/20 (95%)	CYP51A1;SC5D;DHCR7;...
Fanconi anemia pathway	1.79	2.23e-2	36/54 (66.67%)	RPA2;HES1;FANCI;...
Mismatch repair	1.77	2.23e-2	22/23 (95.65%)	RPA2;RFC2;RFC3;...
Oocyte meiosis	1.77	1.86e-2	90/129 (69.77%)	CDC20;CCNB2;PTTG1;...
Base excision repair	1.76	1.70e-2	29/33 (87.88%)	POLE2;PARP2;FEN1;...
Primary immunodeficiency	1.75	1.58e-2	33/38 (86.84%)	IL7R;CD19;CD79A;...
One carbon pool by folate	1.73	1.90e-2	15/20 (75%)	TYMS;MTHFD1;DHFR;...
B cell receptor signaling pathway	1.70	3.49e-2	71/81 (87.65%)	LYN;PPP3CB;CD19;...
Pyrimidine metabolism	1.66	4.53e-2	40/56 (71.43%)	TYMS;DCK;NT5E;...
Cardiac muscle contraction	1.65	4.71e-2	64/87 (73.56%)	ATP2A1;MYL4;CASQ2;...
Terpenoid backbone biosynthesis	1.63	4.92e-2	18/22 (81.82%)	HMGCR;ACAT2;IDI1;...
Nucleotide excision repair	1.63	4.99e-2	40/47 (85.11%)	RPA2;POLE2;RAD23B;...
Complement and coagulation cascades	-1.95	0.00e+0	76/85 (89.41%)	ITGAM;CFHR5;C9;...
Mineral absorption	-1.98	0.00e+0	48/60 (80%)	ATP1A2;MT2A;FTH1;...
Oxidative phosphorylation	-2.17	0.00e+0	93/133 (69.92%)	NDUFV2;ATP6V0E2;NDUFA4;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	4uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.01uM - 2.22uM	24H	Show ▼