Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM1OFHN)

Drug Name
Meglitinides Drug Info
Cross-matching ID
PubChem CID
3033769
ChEBI ID
CHEMBL8809
CAS Number
CAS 84225-95-6
TTD Drug ID
D07MEH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.51 0.00e+0 34/36 (94.44%) FEN1;MCM2;RFC5;...
Fanconi anemia pathway 2.18 0.00e+0 36/54 (66.67%) RAD51;RMI1;FANCG;...
Mismatch repair 2.13 0.00e+0 22/23 (95.65%) RFC5;RFC3;PCNA;...
Base excision repair 1.93 4.75e-3 29/33 (87.88%) FEN1;PCNA;HMGB1;...
Nucleotide excision repair 1.84 1.27e-2 40/47 (85.11%) RFC5;RFC3;PCNA;...
Ribosome 1.82 1.06e-2 113/158 (71.52%) MRPS16;MRPS2;RPS4Y1;...
Homologous recombination 1.82 9.05e-3 35/41 (85.37%) RAD51;BRCA1;RPA2;...
Proteasome 1.78 1.58e-2 44/46 (95.65%) PSMB5;PSMC3;PSMA4;...
Pyrimidine metabolism 1.74 2.32e-2 40/56 (71.43%) CTPS1;CDA;CAD;...
Pentose and glucuronate interconversions 1.72 2.66e-2 17/34 (50%) KL;UGP2;SORD;...
Cell cycle 1.70 2.82e-2 110/124 (88.71%) CDC45;MCM2;CDC20;...
Ribosome biogenesis in eukaryotes 1.66 3.64e-2 52/108 (48.15%) HEATR1;NVL;IMP3;...
African trypanosomiasis -1.69 4.10e-2 32/37 (86.49%) F2RL1;APOA1;PLCB2;...
Sulfur metabolism -1.71 3.60e-2 9/10 (90%) ETHE1;MPST;TST;...
Inositol phosphate metabolism -1.72 3.49e-2 66/73 (90.41%) ITPKA;OCRL;INPP5A;...
Platelet activation -1.73 3.54e-2 106/124 (85.48%) GP1BB;ROCK1;ITGB3;...
Legionellosis -1.73 3.82e-2 51/57 (89.47%) IL1B;HSPA2;IL6;...
TNF signaling pathway -1.74 4.02e-2 103/112 (91.96%) CCL20;CXCL6;CREB3L1;...
Chemokine signaling pathway -1.74 4.27e-2 163/192 (84.9%) GSK3B;CCR10;CRK;...
Estrogen signaling pathway -1.74 4.69e-2 119/137 (86.86%) CREB3L1;MAPK3;KRT18;...
Epithelial cell signaling in Helicobacter pylori infect... -1.89 2.68e-2 62/70 (88.57%) ATP6V1B2;ATP6V1B1;ATP6V0C;...
IL-17 signaling pathway -2.07 1.34e-2 84/94 (89.36%) CCL20;CXCL6;MAPK6;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 10uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H