Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM1OHF8)

Drug Name
lysergol Drug Info
Synonyms lysergole
Cross-matching ID
PubChem CID
14987
ChEBI ID
CHEMBL60528
CAS Number
CAS 602-85-7
TTD Drug ID
D01APL

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Retinol metabolism 1.88 3.15e-2 41/68 (60.29%) UGT2B17;UGT2B15;AOX1;...
Glyoxylate and dicarboxylate metabolism -1.65 4.96e-2 23/30 (76.67%) AMT;CAT;ACO2;...
Autoimmune thyroid disease -1.66 4.60e-2 46/53 (86.79%) HLA-DPB1;FAS;HLA-DOB;...
Aldosterone-regulated sodium reabsorption -1.68 4.19e-2 34/37 (91.89%) PRKCG;PIK3R3;KRAS;...
Ferroptosis -1.74 2.90e-2 36/41 (87.8%) SAT1;GCLM;TFRC;...
Systemic lupus erythematosus -1.75 2.75e-2 45/135 (33.33%) GRIN2A;HLA-DQB1;FCGR3B;...
Neutrophil extracellular trap formation -1.76 2.86e-2 101/189 (53.44%) MAPK14;AGER;TLR7;...
AMPK signaling pathway -1.76 3.10e-2 106/120 (88.33%) STK11;PCK2;CAB39L;...
Type I diabetes mellitus -1.76 3.39e-2 38/43 (88.37%) ICA1;CD86;GAD1;...
Fatty acid biosynthesis -1.76 3.72e-2 16/18 (88.89%) ACSL3;ACACA;FASN;...
Phagosome -1.76 4.14e-2 118/152 (77.63%) STX12;ATP6V1E1;HLA-F;...
Staphylococcus aureus infection -1.81 2.33e-2 72/95 (75.79%) HLA-DOA;KRT18;KRT13;...
Steroid biosynthesis -1.82 2.66e-2 19/20 (95%) FDFT1;EBP;SQLE;...
Toll-like receptor signaling pathway -1.86 2.48e-2 94/104 (90.38%) TNF;IRF7;MAP2K7;...
PPAR signaling pathway -1.91 1.74e-2 66/74 (89.19%) PCK2;FABP6;ACOX1;...
Type II diabetes mellitus -2.02 9.31e-3 42/46 (91.3%) IKBKB;PIK3R2;MAPK10;...
Graft-versus-host disease -2.02 1.24e-2 32/42 (76.19%) HLA-DPB1;FAS;TNF;...
Asthma -2.07 1.24e-2 25/31 (80.65%) FCER1A;HLA-DQB1;MS4A2;...
Allograft rejection -2.24 1.24e-2 32/38 (84.21%) HLA-A;HLA-DQB1;HLA-DPB1;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H