Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM1SON5)

Drug Name
5H-6-thia-4,5-diaza-chrysene 6,6-dioxide Drug Info
Synonyms
MLS000038106; SMR000040050; 5H-quinolino[8,7-c][1,2]benzothiazine 6,6-dioxide; 5H-6-thia-4,5-diaza-chrysene 6,6-dioxide; Oprea1_666568; CBDivE_011354; CHEMBL428064; cid_659101; AC1LD057; CHEMBL1589921; SCHEMBL11973195; BDBM36894; CHEBI:93609; MolPort-002-134-452; CYSOFAOLQAYKGU-UHFFFAOYSA-N; HMS2479M21; ZINC230033; DNDI1318477; STL328289; AKOS022139691; MCULE-7323909600; NCGC00070544-03; EU-0033328; SR-01000388300; 5H-quino[8,7-c][1,2]benzothiazine 6,6-dioxide; SR-01000388300-1
Cross-matching ID
PubChem CID
659101
ChEBI ID
CHEMBL428064
TTD Drug ID
D0Q2KK

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Mineral absorption 2.58 0.00e+0 48/60 (80%) HMOX1;MT1M;SLC30A1;...
HIF-1 signaling pathway 2.18 0.00e+0 105/109 (96.33%) HMOX1;PFKFB3;CDKN1A;...
Legionellosis 2.12 0.00e+0 51/57 (89.47%) HSPA1A;HSPA6;BNIP3;...
Thyroid cancer 2.02 8.40e-3 36/37 (97.3%) GADD45B;CDKN1A;LEF1;...
Fluid shear stress and atherosclerosis 1.96 8.96e-3 123/139 (88.49%) HMOX1;FOS;JUN;...
Lipid and atherosclerosis 1.95 1.12e-2 190/215 (88.37%) HSPA1A;HSPA6;FOS;...
Protein processing in endoplasmic reticulum 1.94 9.60e-3 127/171 (74.27%) HSPA1A;HSPA6;PPP1R15A;...
Antigen processing and presentation 1.90 1.40e-2 60/78 (76.92%) HSPA1A;HSPA6;HSPA8;...
MAPK signaling pathway 1.89 1.24e-2 272/294 (92.52%) HSPA1A;HSPA6;GADD45B;...
IL-17 signaling pathway 1.85 1.57e-2 84/94 (89.36%) FOS;FOSB;FOSL1;...
Estrogen signaling pathway 1.85 1.43e-2 119/137 (86.86%) HSPA1A;HSPA6;FOS;...
Ferroptosis 1.85 1.31e-2 36/41 (87.8%) HMOX1;GCLM;SAT1;...
Transcriptional misregulation in cancer 1.83 1.21e-2 158/192 (82.29%) GADD45B;CDKN1A;CXCL8;...
Colorectal cancer 1.83 1.12e-2 84/86 (97.67%) GADD45B;FOS;CDKN1A;...
Prostate cancer 1.83 1.12e-2 93/97 (95.88%) CDKN1A;NKX3-1;PDGFA;...
Pertussis 1.82 1.19e-2 64/76 (84.21%) FOS;JUN;CXCL8;...
Parathyroid hormone synthesis, secretion and action 1.82 1.12e-2 98/106 (92.45%) FOS;NR4A2;CDKN1A;...
Basal cell carcinoma 1.82 1.06e-2 41/63 (65.08%) GADD45B;CDKN1A;BMP2;...
FoxO signaling pathway 1.79 1.36e-2 118/131 (90.08%) GADD45B;BNIP3;CDKN1A;...
Longevity regulating pathway 1.79 1.29e-2 90/151 (59.6%) HSPA1A;HSPA6;HSPA8;...
Breast cancer 1.77 1.65e-2 119/147 (80.95%) GADD45B;FOS;CDKN1A;...
Endometrial cancer 1.77 1.63e-2 56/58 (96.55%) GADD45B;CDKN1A;GSK3B;...
Pathways in cancer 1.76 1.75e-2 474/531 (89.27%) HMOX1;GADD45B;FOS;...
Spliceosome 1.76 1.77e-2 101/150 (67.33%) HSPA1A;HSPA6;HSPA8;...
Endocytosis 1.72 2.29e-2 198/252 (78.57%) HSPA1A;HSPA6;HSPA8;...
Renal cell carcinoma 1.70 2.41e-2 68/69 (98.55%) CDKN1A;JUN;SLC2A1;...
Hippo signaling pathway 1.70 2.53e-2 120/186 (64.52%) BMP2;SMAD3;GSK3B;...
Hepatocellular carcinoma 1.69 2.60e-2 135/168 (80.36%) HMOX1;GADD45B;CDKN1A;...
Mitophagy 1.68 2.82e-2 56/68 (82.35%) BNIP3;JUN;BNIP3L;...
TGF-beta signaling pathway 1.67 3.06e-2 81/94 (86.17%) ID3;BMP2;SMAD3;...
Cysteine and methionine metabolism -1.69 3.90e-2 43/50 (86%) AHCY;ENOPH1;PHGDH;...
Mismatch repair -1.71 3.47e-2 22/23 (95.65%) EXO1;RPA2;RPA1;...
Progesterone-mediated oocyte maturation -1.71 3.73e-2 75/100 (75%) ANAPC5;ADCY1;CDK1;...
Pantothenate and CoA biosynthesis -1.73 3.40e-2 14/21 (66.67%) PANK3;DPYS;ALDH1B1;...
Aminoacyl-tRNA biosynthesis -1.78 2.45e-2 15/66 (22.73%) GATB;IARS2;DARS2;...
Base excision repair -1.80 2.86e-2 29/33 (87.88%) MUTYH;POLE3;APEX1;...
Tryptophan metabolism -2.02 5.45e-3 35/42 (83.33%) KYNU;HADH;ACAT1;...
DNA replication -2.08 0.00e+0 34/36 (94.44%) DNA2;RPA2;POLE3;...
Citrate cycle (TCA cycle) -2.16 0.00e+0 30/30 (100%) PC;CS;MDH1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.002uM - 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 10uM 6H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.002uM - 10uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 10uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM 6H